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Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Joint Authors
Zhang, Jiayuan
Wang, Yunxia
Jin, Yuxia
Zhang, Qi
Xiao, Xiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To determine the effectiveness and safety of acupuncture for perimenopausal depression.
Methods.
We searched the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, CNKI, VIP Citation Databases, Wan Fang, and online trial registries such as ClinicalTrials.gov for randomized controlled trials (RCTs) assessing the efficacy and safety of acupuncture for perimenopausal depression.
Literature screening, data extraction, and determination of the risk of bias were performed by two researchers independently.
The extracted data were pooled and meta-analyzed using RevMan5.3 software.
Results.
In total, 16 RCTs covering 1311 patients were enrolled.
Overall, the results showed that acupuncture was more effective in the treatment of perimenopausal depression than antidepressants (OR = 2.68, 95% CI (1.84, 3.90), P<0.00001).
Furthermore, HAMD scores in the manual acupuncture group and electroacupuncture group were lower than those of antidepressants (manual acupuncture vs.
antidepressants (MD = −2.35, 95% CI (−2.93, −1.77), P<0.00001) and electroacupuncture vs.
antidepressants (MD = −1.2, 95% CI (−1.92, −0.48), P=0.001)).
Data analysis revealed that the treatment effect of acupuncture was more stable than that of antidepressants (MD = −2.4, 95% CI (−3.37, −1.43), P<0.00001).
Moreover, acupuncture was safer than antidepressants based on the incidence of adverse events (OR = 0.23, 95% CI (0.1, 0.52), P=0.0004).
But acupuncture has no effect on estrogen levels (P≥0.05).
Conclusions.
Acupuncture for perimenopausal depression is safe and effective.
Moreover, it has more stable long-term effects than antidepressants and hormone replacement therapy (HRT).
We recommend acupuncture as a clinical treatment of perimenopausal depression.
American Psychological Association (APA)
Xiao, Xiao& Zhang, Jiayuan& Jin, Yuxia& Wang, Yunxia& Zhang, Qi. 2020. Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156769
Modern Language Association (MLA)
Xiao, Xiao…[et al.]. Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156769
American Medical Association (AMA)
Xiao, Xiao& Zhang, Jiayuan& Jin, Yuxia& Wang, Yunxia& Zhang, Qi. Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156769