A Pilot Study to Assess Food Safety and Potential Cholesterol-Lowering Efficacy of Antrodia cinnamomea Solid-State Cultivated Mycelium in Healthy Adults

Abstract EN

Antrodia cinnamomea is a Taiwanese medicinal mushroom with multiple pharmacological activities.

Antrodia cinnamomea solid-state cultivated mycelium (LAC) exerts health-related effects in animal and cell models, but clinical data is limited.

This study aimed to determine the safety and effects of LAC on human physiological functions.

In an open-label, single-arm study, 32 healthy men and women ingested LAC capsules for three months.

The subjects were monitored during the study and one month after the study end-point.

LAC consumption did not significantly change fasting blood glucose, blood pressure, and triglyceride levels or liver and renal function indices.

No adverse events occurred during the trial.

Moreover, a significant change from baseline in total cholesterol levels was observed; men and women had decreases of 5.7% and 5.3%, respectively.

Based on these, the ingestion of LAC-capsule has a considerable degree of safety and has the potential to reduce total cholesterol in healthy adults.