Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats

Joint Authors

Tastekin, Bora
Pelit, Aykut
Polat, Sait
Tuli, Abdullah
Sencar, Leman
Alparslan, Mustafa Muhlis
Daglioglu, Yusuf Kenan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-16

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Aims.

The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4′-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4′ trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats.

Materials and Methods.

At the end of the 5-week experimental period, the right gastrocnemius muscles of the rats were examined biomechanically, while the left ones were examined histologically.

In addition, blood glucose, serum insulin, and malondialdehyde (MDA) levels were analyzed in blood samples taken from the rats.

Results.

The skeletal muscle isometric contraction forces, which showed a decrease with diabetes, were observed to increase with antioxidant applications.

Blood glucose, serum insulin, and MDA levels in diabetic rats approached normal levels after applying PTS.

When the electron microscopic images of the rat skeletal muscle were examined, those in the combination treatment group were observed to show a better enhancement in the skeletal muscle morphological structure compared to the other diabetic and treatment groups.

Conclusion.

According to the findings, we suggest that these antioxidant treatments might have good therapeutic nutraceutical potential for some muscle diseases that coexist with diabetes.

These treatments should be comprehensively investigated in the future.

American Psychological Association (APA)

Tastekin, Bora& Pelit, Aykut& Polat, Sait& Tuli, Abdullah& Sencar, Leman& Alparslan, Mustafa Muhlis…[et al.]. 2018. Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156779

Modern Language Association (MLA)

Tastekin, Bora…[et al.]. Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156779

American Medical Association (AMA)

Tastekin, Bora& Pelit, Aykut& Polat, Sait& Tuli, Abdullah& Sencar, Leman& Alparslan, Mustafa Muhlis…[et al.]. Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156779

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1156779