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Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers
Joint Authors
Lee, Young
Kang, Hae Yeon
Choe, Eun Kyung
Park, Kyu Joo
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Serum carcinoembryonic antigen (CEA) is a well-known tumor marker for colorectal adenocarcinoma.
However, CEA levels can be influenced by various nonmalignant conditions.
A retrospective, cross-sectional study was performed including 18,131 healthy nonsmokers who underwent health check-ups with evaluation of the serum CEA level.
In the training set, multivariate analysis revealed that the log-transformed CEA level had positive relationships with age (regression coefficient (r) = 0.005, P<0.001), white blood cell (WBC) count (r=0.007, P=0.016), hemoglobin (HB, r=0.016, P<0.001), aspartate aminotransferase (AST, r=0.002, P=0.005), creatinine (r=0.076, P=0.038), and glycosylated hemoglobin (HbA1c, r=0.052, P<0.001); body mass index (BMI, r=−0.007, P<0.001) showed a negative correlation.
The results for age, BMI, WBC count, HB, AST, and HbA1c were validated in the test set.
We were able to construct the following model to predict the log-transformed CEA level: log (CEA + 0.51) = −0.204 − 0.051 (gender) + 0.005 (age) − 0.006 (BMI) + 0.008 (WBC count) + 0.016 (HB) + 0.002 (AST) + 0.062 (creatinine) + 0.054 (HbA1c).
For colorectal cancer prediction, the model with the observed CEA and adjusted CEA levels had significantly high predictive power (AUC 0.756, P<0.001) than the model only including the observed CEA level (AUC 0.693, P<0.001).
Factors influencing serum CEA levels should be adjusted before clinical interpretation to increase the predictive value of CEA.
American Psychological Association (APA)
Kang, Hae Yeon& Choe, Eun Kyung& Park, Kyu Joo& Lee, Young. 2017. Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156801
Modern Language Association (MLA)
Kang, Hae Yeon…[et al.]. Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156801
American Medical Association (AMA)
Kang, Hae Yeon& Choe, Eun Kyung& Park, Kyu Joo& Lee, Young. Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156801