Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database
Joint Authors
Lu, Yen-Chu
Yang, Ching-Wei
Lin, Yi-Hsuan
Hsueh, Ju-Yu
Chen, Jiun-Liang
Yang, Sien-Hung
Chen, Yu-Chun
Chen, Hsing-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background and Purpose.
Allergic rhinitis (AR) is a highly prevalent disease, and Chinese herbal medicine (CHM) is commonly used for treating AR.
This study aims to demonstrate the CHM network for AR and possible molecular pathways.
Materials and Methods.
Patients with a primary diagnosis of AR (ICD-9-CM code: 477.9) in 2010 were included, and the National Health Insurance Research Database in Taiwan was used as the data source.
Association rule mining and social network analysis were used to establish and explore the CHM network.
Possible molecular pathways of the CHM network were summarized and compared with commonly used western medicine (WM) by conducting overrepresentation analysis in the Reactome pathway database.
The potential proteins acted by CHMs were obtained from the CHM ingredient-protein databases, including STITCH, TCMSP, TCMID, and TCM@Taiwan.
Results.
There were 89,148 AR subjects found in 2010, and a total of 33,507 patients ever used CHM.
On an average, 5.6 types of CHMs were utilized per prescription.
Xin-Yi-Qing-Fei-Tang was used most frequently (25.5% of 222,279 prescriptions), while Xiao-Qing-Long-Tang with Xin-Yi-San was the most commonly prescribed CHM-CHM combination.
Up to six distinctive clusters could be found among the CHM network, and core CHMs could be found for AR, such as Xiao-Qing-Long-Tang and Xin-Yi-Qing-Fei-Tang.
A total of 140 molecular pathways were covered by the CHM network (2,432 ingredients from 31 kinds of CHMs), while 39 WMs covered 55 pathways.
Among pathways responding to the immune system, WM mainly acted on cytokine signaling-related pathways, while CHM mostly acted on neutrophil/macrophage-related innate pathways and dendritic cell-related adaptive immunity pathways.
Conclusion.
Our study demonstrated and analyzed the CHM network for AR.
Core CHM for AR and possible molecular pathways were presented as well, and this information is crucial for researchers to select candidates for CHM-related studies.
American Psychological Association (APA)
Lu, Yen-Chu& Yang, Ching-Wei& Lin, Yi-Hsuan& Hsueh, Ju-Yu& Chen, Jiun-Liang& Yang, Sien-Hung…[et al.]. 2020. Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1156805
Modern Language Association (MLA)
Lu, Yen-Chu…[et al.]. Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1156805
American Medical Association (AMA)
Lu, Yen-Chu& Yang, Ching-Wei& Lin, Yi-Hsuan& Hsueh, Ju-Yu& Chen, Jiun-Liang& Yang, Sien-Hung…[et al.]. Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real-World Database. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1156805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156805