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Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins
Joint Authors
Zeng, Mengnan
Zhang, Beibei
Li, Benke
Kan, Yuxuan
Wang, Shengchao
Feng, Weisheng
Zheng, Xiaoke
Wang, Yangyang
Xu, Ruiqi
Wu, Yuanyuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Corallodiscus flabellata B.
L.
Burtt is a traditional Chinese medicine.
Previous studies in our laboratory showed that C.
flabellata alleviated symptoms of Alzheimer’s disease (AD) in a rat model of AD and increased healthy rats’ urine volume.
The aims of this study were to explore the diuretic activity of different extracts from C.
flabellata and to identify the underlying mechanisms of action.
Different doses of a C.
flabellata extract (CF-L, CF-M, and CF-H) were administered orally to male KM mice in a single dose.
In another procedure, C.
flabellata (CF), water extract, and 20%, 30%, and 40% ethanol extracts of C.
flabellata (CF-WE, CF-20, CF-30, and CF-40) were administered orally daily for 5 days.
The urinary excretion rate, osmolality, and electrolyte levels in urine and serum, renal expression of aquaporins (AQPs), apoptosis-related protein, and MAPK-related protein were analyzed.
The results showed that single doses of CF-M and CF-H increased urinary volume significantly, as well as daily administration of CF, CF-WE, CF-20, CF-30, and CF-40.
Furthermore, CF-20 and CF-30 increased the concentration of Na+ in the urine.
Treatment with CF-40 increased the urine osmolality and Na+ and Cl− concentrations and decreased the concentration of Na+ in the serum.
Also, CF, CF-WE, CF-20, CF-30, and CF-40 decreased the renal expression of AQPs, as well as the ratios of Bcl-2/Bax, p-ERK/ERK, p-JNK/JNK, and p-p38/p38.
In sum, the medium and high doses of the C.
flabellata extract and CF-WE, CF-20, CF-30, and CF-40 were found to have a diuretic activity.
They may inhibit the renal expression of AQPs and apoptosis-related proteins by inhibiting the MAPK signaling pathway, thereby achieving diuretic effects.
American Psychological Association (APA)
Kan, Yuxuan& Zeng, Mengnan& Zhang, Beibei& Li, Benke& Wang, Shengchao& Wang, Yangyang…[et al.]. 2020. Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156807
Modern Language Association (MLA)
Kan, Yuxuan…[et al.]. Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156807
American Medical Association (AMA)
Kan, Yuxuan& Zeng, Mengnan& Zhang, Beibei& Li, Benke& Wang, Shengchao& Wang, Yangyang…[et al.]. Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156807