Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress
Joint Authors
Chen, Yumin
Zhang, Xinying
Yin, Yonghui
Zhu, Ranran
Li, Xiaoli
Li, Hui
Li, Li
Wang, Zichen
Zhou, Ji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Vascular endothelial dysfunction is an essential and early sign of diabetic macroangiopathy, a primary complication of diabetes mellitus.
Astragalus membranaceous-Angelica sinensis is a classic medical combination applied in China to treat diabetes mellitus.
The aim of this study was to investigate the effect of the granule form of the extract produced from the dried root of Astragalus membranaceous (AM) combination with the granule form of the extract produced from the dried Angelica sinensis (AS) on diabetic macroangiopathy and its underlying mechanism.
Herein, rats were treated by AM-AS at a ratio of 3 : 2 via intragastric administration.
High glucose-induced human umbilical vein vascular endothelial cells (HUVECs) were then treated with drug-containing serum collected from the rats.
In high glucose-treated HUVECs, AM-AS combination increased cell viability (P<0.05), decreased the percentage of apoptotic cells (P<0.05) and the expression of the proapoptosis protein caspase 3 (P<0.05), reduced the proportion of cells in the G0/G1 phase (P<0.05), decreased reactive oxygen species level (P<0.05), enhanced cell migration and invasion (P<0.05), and reduced the level of 8-iso-prostaglandin F2alpha.
These results indicate that AM-AS combination at the ratio of 3 : 2 ameliorated HUVEC dysfunction by regulating apoptosis, cell migration, and invasion, which might be mediated by their regulatory effect on reactive oxygen species production.
The current study provides a theoretical basis for the treatment of diabetic macroangiopathy using AM-AS.
American Psychological Association (APA)
Yin, Yonghui& Li, Hui& Chen, Yumin& Zhu, Ranran& Li, Li& Zhang, Xinying…[et al.]. 2020. Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156823
Modern Language Association (MLA)
Yin, Yonghui…[et al.]. Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156823
American Medical Association (AMA)
Yin, Yonghui& Li, Hui& Chen, Yumin& Zhu, Ranran& Li, Li& Zhang, Xinying…[et al.]. Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156823