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Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic
Joint Authors
Kamaruzaman, Khaidatul Akmar
Aizat, Wan Mohd
Mat Noor, Mahanem
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Gynura procumbens (GP) is a medicinal herb that has long been known as anti-inflammatory and antihyperglycaemic.
Recently, this herbal extract has been associated with a profertility effect, suggesting its applicability in treating both diabetes and male infertility.
In this study, the effects of GP aqueous extract (GPAE) on diabetic rats were investigated through evaluating testes histology and androgen hormone levels as well as the implantation sites of female rats on copulation with the treated male rats.
Three dosages of GPAE were used (150, 300, and 450 mg/kg), and there were three control groups [normal, diabetic, and metformin-treated diabetic].
Testes histology, androgen hormone levels, and number of implantation sites of the GPAE-treated groups matched those of the normal group in contrast to the diabetic and metformin-treated diabetic controls.
Sperm proteomics analysis identified 666 proteins, but only 88 were consistently found in all the control and 450-mg/kg GPAE-treated groups.
Four proteins, including cysteine-rich secretory protein 1, carboxylesterase 5A, zona pellucida binding protein, and phosphatidylethanolamine-binding protein 1, were significantly upregulated with GPAE treatment compared with the diabetic control, matching the protein levels of the normal group.
These proteins were mainly involved in sperm maturation, sperm capacitation, and sperm-egg interaction, suggesting that GP treatment was able to restore the fertility of male diabetic rats at molecular protein level.
In conclusion, GP treatment effectively treats infertility of male diabetic rats, possibly through the upregulation of proteins related to sperm maturation and sperm-egg interaction.
American Psychological Association (APA)
Kamaruzaman, Khaidatul Akmar& Aizat, Wan Mohd& Mat Noor, Mahanem. 2018. Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156828
Modern Language Association (MLA)
Kamaruzaman, Khaidatul Akmar…[et al.]. Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156828
American Medical Association (AMA)
Kamaruzaman, Khaidatul Akmar& Aizat, Wan Mohd& Mat Noor, Mahanem. Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156828