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Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To investigate the potential therapy targets and pharmacological mechanism of traditional Chinese medicine (TCM) Xihuang pill in liver cancer based on network pharmacology.
Methods.
Drug ingredients-target network was constructed based on the target sets of Xihuang pill and liver cancer.
The overlapping genes between Xihuang pill targets and liver cancer-related molecular targets were investigated using comparative analysis.
Moreover, the PPI network and module was constructed based on overlapping genes and hub nodes, respectively, followed by the pathway enrichment analysis.
Results.
A drug ingredients-target network was established with 1184 nodes and 11035 interactions.
Moreover, a total of 106 overlapping genes were revealed between drug targets and liver cancer molecular targets.
Furthermore, a PPI network and 4 modules were further investigated based on overlapping genes, respectively.
These hub nodes such as VEGFA and EGFR were mainly enriched in GO functions including positive regulation of MAP kinase activity, activation of protein kinase activity, regulation of MAP kinase activity, and pathways like proteoglycans in cancer, bladder cancer, and estrogen signaling.
Conclusion.
VEGFA and EGFR might be potential therapy targets of Xihuang pill in liver cancer.
Furthermore, the effect of Xihuang pill on liver cancer might be realized by targeting VEGFA and EGFR in pathways like proteoglycans in cancer and estrogen signaling.
American Psychological Association (APA)
Zhao, Xu& Hao, Jian& Chen, Sinuan. 2020. Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156853
Modern Language Association (MLA)
Zhao, Xu…[et al.]. Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156853
American Medical Association (AMA)
Zhao, Xu& Hao, Jian& Chen, Sinuan. Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156853