Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial
Joint Authors
Pang, Yu-yang
Li, Yan
Kui, Gang
Tang, Yong
Wang, Yong-ling
Cao, Zhen-dong
Zhu, Qi
Liao, Ming-juan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The randomized controlled trial was to evaluate the efficacy of topical Chinese herbal Zhangpi Ointment for hydroxyurea-induced leg ulcers in patients with myeloproliferative neoplasms.
Patients and Methods.
This single-center, prospective, randomized, open-label, controlled clinical trial conducted at Shanghai Ninth People’s Hospital enrolled 54 patients with hydroxyurea-induced leg ulcers.
Patients were randomly assigned to the control group (n = 27) treated with chlorhexidine dressing or the intervention group (n = 27) treated with the Zhangpi Ointment.
Finally, 26 patients in the control group and 23 patients in the intervention group completed 8 weeks of observation.
Results.
The rate of complete healing was 100% for the intervention group, which was significantly higher than that of the control group (96.15%) (P<0.05).
Furthermore, the intervention group achieved a significantly higher rate of wound healing (95.56%) than the control group (69.02%) at week 4 (P<0.01).
The intervention group took 34 ± 5 days to achieve complete healing while the control group took 41 ± 7 days (P < 0.01).
Moreover, grade 3/4 side effects were observed in neither group.
Conclusion.
The Zhangpi Ointment is effective in promoting the healing of hydroxyurea-induced leg ulcers in patients with myeloproliferative neoplasms, providing a therapeutic option for a condition that is recalcitrant to conventional therapy.
American Psychological Association (APA)
Pang, Yu-yang& Li, Yan& Kui, Gang& Tang, Yong& Liao, Ming-juan& Wang, Yong-ling…[et al.]. 2018. Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156873
Modern Language Association (MLA)
Pang, Yu-yang…[et al.]. Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156873
American Medical Association (AMA)
Pang, Yu-yang& Li, Yan& Kui, Gang& Tang, Yong& Liao, Ming-juan& Wang, Yong-ling…[et al.]. Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156873