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Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat
Joint Authors
Zhao, Haiyu
Bian, Baolin
Yang, Jian
Wang, Hongjie
Gu, Xinru
Zhou, Junyi
Zhou, Yanyan
Wei, Xiaolu
Ren, Wei
Si, Nan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ameliorative effects on learning and memory deficits of Alzheimer’s disease (AD).
The current study aims to reveal the underlying mechanism of HLJDD in the treatment of AD by simultaneous determination on the regulation of HLJDD on oxidative stress, neurotransmitters, and AMPK-SIRT1 pathway in AD.
AD model rat was successfully established by injection of D-galactose and Aβ25-35-ibotenic acid.
Morris Water Maze (MWM) test was used to evaluate the success of AD modelling.
On this basis, an advanced technique with UPLC-QqQ MS/MS was built up and applied to determine the levels of 8 neurotransmitters in rat plasma.
Significant alternation in methionine, glutamine, and tryptophan was observed in AD rats’ plasma after the administration of HLJDD, relative to the model group.
Meanwhile, HLJDD could upregulate the levels of SOD, GSH-Px, AMPK, and SIRT1 and downregulate the content of MDA in the peripheral system of the AD rats.
The underlying therapeutic mechanism of HLJDD for the treatment of AD was associated with alleviating oxidation stress, inflammation, neurotransmitters, and energy metabolism.
These data provide solid foundation for the potential use of HLJDD to treat AD.
American Psychological Association (APA)
Gu, Xinru& Zhao, Haiyu& Zhou, Junyi& Zhou, Yanyan& Wei, Xiaolu& Wang, Hongjie…[et al.]. 2020. Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156878
Modern Language Association (MLA)
Gu, Xinru…[et al.]. Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156878
American Medical Association (AMA)
Gu, Xinru& Zhao, Haiyu& Zhou, Junyi& Zhou, Yanyan& Wei, Xiaolu& Wang, Hongjie…[et al.]. Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156878