Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach
Joint Authors
Huang, Shao-jie
Mu, Fei
Li, Fei
Wang, Wen-jun
Zhang, Wei
Lei, Lu
Ma, Yang
Wang, Jing-wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
The purpose of this work was to investigate the bioactive compounds, core genes, and pharmacological mechanisms and to provide a further research orientation of Erzhi pill (EZP) on drug-induced liver injury (DILI).
Methods.
At first, we collected information of bioactive compounds of EZP from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and previous studies.
And then, the targets related to bioactive compounds and DILI were obtained from 4 public databases.
At last, Cytoscape was used to establish a visual network.
Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and network analysis were performed to investigate potential mechanism of EZP against DILI.
Results.
A total of 23 bioactive compounds and 89 major proteins of EZP were screened out as potential players against DILI.
Association for bioactive compounds, core targets, and related pathways was analyzed, implying that core targets related to these pathways are ALB, AKT1, MAPK1, EGFR, SRC, MAPK8, IGF1, CASP3, HSP90AA1, and MMP9, and potential mechanisms of EZP acting on DILI are closely related to negative regulation of apoptosis process, improvement of lipid metabolism, and positive regulation of liver regeneration process.
Conclusion.
This study demonstrated the multicompound, multitarget, and multichannel characteristics of EZP, which provided a novel approach for further research the mechanism of EZP in the treatment of DILI.
American Psychological Association (APA)
Huang, Shao-jie& Mu, Fei& Li, Fei& Wang, Wen-jun& Zhang, Wei& Lei, Lu…[et al.]. 2020. Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156882
Modern Language Association (MLA)
Huang, Shao-jie…[et al.]. Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1156882
American Medical Association (AMA)
Huang, Shao-jie& Mu, Fei& Li, Fei& Wang, Wen-jun& Zhang, Wei& Lei, Lu…[et al.]. Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156882