Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus
Joint Authors
Ma, Jie
Liu, Yan
Yu, Xue
Wu, Fengzhi
Han, Chenxia
Li, Feng
Wu, Xiumei
Zhang, Weiyue
Li, Danxi
Chen, Dou
Dai, Ning
Lin, Bingqi
Mao, Meng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The traditional Chinese medicine (TCM) decoction Si-Ni-San (SNS) has been utilised for millennia to improve physiological coordination of the functions of the liver and spleen, which are regarded as the main pathological organs of central fatigue in TCM.
This study evaluates the effect of a modified SNS (MSNS) formula on central fatigue in rats and explores molecular changes associated with hippocampal mitochondrial biogenesis.
Central fatigue was induced through a 21-day sleep deprivation protocol.
We assessed MSNS’s effects on behaviour, blood and liver biomarkers, and mitochondrial ultrastructure.
We found that MSNS could reverse various signs of central fatigue such as its effects on hippocampal gene and protein expression levels of sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), and nuclear respiratory factor 1 (NRF1).
We also observed evidence of MSNS decreasing central fatigue, such as decreasing creatine kinase activity, decreasing levels of malondialdehyde and blood urea nitrogen, increasing lactate dehydrogenase and superoxide dismutase activities, increasing mitochondrial DNA copy number, and reversing mitochondrial ultrastructure changes.
These findings suggest that MSNS can ameliorate central fatigue and that its molecular mechanism involves mitochondrial biogenesis enhancement mediated by hippocampal SIRT1, PGC-1α, and NRF1.
American Psychological Association (APA)
Han, Chenxia& Li, Feng& Liu, Yan& Ma, Jie& Yu, Xue& Wu, Xiumei…[et al.]. 2018. Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1156899
Modern Language Association (MLA)
Han, Chenxia…[et al.]. Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1156899
American Medical Association (AMA)
Han, Chenxia& Li, Feng& Liu, Yan& Ma, Jie& Yu, Xue& Wu, Xiumei…[et al.]. Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1156899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156899