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In Vivo Study on Site of Action of Sinapine Thiocyanate following Acupoint Herbal Patching
Joint Authors
Xuan, Li-Hua
Chen, Shan
Jin, Yu-Tong
Zhu, Zheng-Yang
Wu, Ling-Tao
Yang, Ping
Jin, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the site of action of sinapine thiocyanate (ST), following acupoint herbal patching (AHP).
Methods.
Twenty Wistar rats were randomized into five groups (groups A, B, C, D, and E), and all groups received the same AHP in vivo.
Skin samples were excised at 2 h, 4 h, 6 h, 10 h, and 26 h after AHP administration from group A to group E separately and the concentrations of ST in the skin were determined using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method.
A pharmacokinetic profile of ST following AHP was performed at the same time in a group of five Wistar rats to detect plasma levels at the same time intervals.
Results.
The mean ± SD ST concentrations (ng/ml) at 2 h (group A), 4 h (group B), 6 h (group C), 10 h (group D), and 26 h (group E) after AHP administration were 250.01±61.99, 61.01±30.41, 40.12±26.94, 78.66±59.43, and 19.55±18.95, respectively.
No ST was detected in rats’ plasma samples at the same time points.
Conclusions.
The site of action of ST following AHP is in the skin.
American Psychological Association (APA)
Chen, Shan& Jin, Yu-Tong& Zhu, Zheng-Yang& Wu, Ling-Tao& Yang, Ping& Jin, Ping…[et al.]. 2018. In Vivo Study on Site of Action of Sinapine Thiocyanate following Acupoint Herbal Patching. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1156908
Modern Language Association (MLA)
Chen, Shan…[et al.]. In Vivo Study on Site of Action of Sinapine Thiocyanate following Acupoint Herbal Patching. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1156908
American Medical Association (AMA)
Chen, Shan& Jin, Yu-Tong& Zhu, Zheng-Yang& Wu, Ling-Tao& Yang, Ping& Jin, Ping…[et al.]. In Vivo Study on Site of Action of Sinapine Thiocyanate following Acupoint Herbal Patching. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1156908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156908