Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity Syndrome in Hypertensive Patients
Joint Authors
Luo, Jie-wei
Zheng, Xing-yu
Lin, Cong-huai
Zhu, Yao-bin
Wu, Yong-xi
Chen, Wei-wei
Yang, Xiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Structural changes in symbiotic human microorganisms can affect host phenotype.
Liver-fire hyperactivity syndrome (LFHS) presents as bitter taste, halitosis, xerostomia, odontalgia, and other oral symptoms.
LFHS is associated with hypertension (EH).
In this study, tongue flora was analyzed to further understand the intrinsic relationship between tongue flora and LFHS.
Samples of tongue coating, from 16 patients with EH-LFHS, 16 with EH-non-LFHS, and 16 controls, were obtained; then, 16S rRNA variable (V3-V4) regions were amplified and sequenced by MiSeq PE300 Sequencing.
Tag clustering and Operational Taxonomic Units (OTUs) abundance analysis were used to compare the OTU sequence with the 16S database.
The species were classified, and diversity and structure of the bacterial flora were compared between the three groups.
Alpha diversity analysis, including Observed Species index and Chao index, indicated significantly higher richness of species in patients with EH-LFHS (p<0.05).
Higher phylogenetic diversity, in patients with EH-non-LFHS, indicates greater differences in evolutionary history than in patients with EH-LFHS.
Streptococcus, Rothia, Neisseria, and Sphingomonas were the most prevalent in patients with EH-LFHS, differed from the other two groups.
This indicates that richer bacterial diversity, and structure associated with EH-LFHS, may affect the occurrence, development, and outcome of hypertension and syndrome subtypes recognized by TCM.
American Psychological Association (APA)
Luo, Jie-wei& Lin, Cong-huai& Zhu, Yao-bin& Zheng, Xing-yu& Wu, Yong-xi& Chen, Wei-wei…[et al.]. 2018. Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity Syndrome in Hypertensive Patients. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156917
Modern Language Association (MLA)
Luo, Jie-wei…[et al.]. Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity Syndrome in Hypertensive Patients. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156917
American Medical Association (AMA)
Luo, Jie-wei& Lin, Cong-huai& Zhu, Yao-bin& Zheng, Xing-yu& Wu, Yong-xi& Chen, Wei-wei…[et al.]. Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity Syndrome in Hypertensive Patients. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156917