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Preclinical Evidence and Mechanism of Xingnaojing Injection for Cerebral Ischemia: A Systematic Review and Meta-Analysis of Animal Studies
Joint Authors
Dong, Taiwei
Wang, Jian
Ma, Rong
Wen, Jianxia
Chen, Nian
Xie, Qian
Ma, Xiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
Cerebral ischemia can cause severe harm to people’s health with the characteristics of high incidence, high disability, and high mortality.
Xingnaojing injection (XNJI) is widely used in the treatment of cerebral ischemia.
The aim of this review is to evaluate the efficacy and mechanism of XNJI in animal models of cerebral ischemia.
Methods.
Total seven electronic databases in English or Chinese (CNKI, Wanfang, VMIS, PubMed, MEDLINE, Embase, and the Cochrane Library) about most experiments and studies which came out before June 2018 of XNJI for cerebral ischemia have been searched.
Data extraction, quality assessment, and meta-analysis are conducted according to the Cochrane standards and RevMan 5.3 software.
Results.
We have identified 23 eligible studies and made a meta-analysis based on these studies.
Meta-analysis shows that XNJI contributes significantly to reduction in neurological deficit score (P = 0.0002, MD = −1.25, 95% CI: −1.92, −0.58) compared with the control group of cerebral ischemia.
Subgroup analytic results demonstrate that XNJI has been more effective in animal model of cerebral ischemia-reperfusion injury (P = 0.009, MD = −1.35, 95%CI: −2.36, −0.34) than that of permanent cerebral ischemia (P = 0.0002, MD = −1.08, 95%CI: −1.66, −0.51).
Compared with control group, XNJI could remarkably reduce cerebral infarction area (P < 0.00001, MD = −14.98, 95%CI: −21.36, −8.59), brain edema (P < 0.00001, MD = −4.64, 95%CI: −5.38, −3.90), and neuronal cell apoptosis (P < 0.0001, MD = −12.21, 95%CI: 18.05, −6.37).
Meanwhile, the meta-analysis shows that XNJI has a significant anti-inflammatory effect, and the levels of TNF-α, IL-6, and IL-1β are significantly reduced by XNJI (P = 0.001, MD = −4.13, 95%CI:−6.68, −1.58; P < 0.00001, MD = −119.23, 95%CI: −138.04, −100.43; P = 0.21, MD = −228.69, 95% CI: −586.20, 128.83).
Additionally, XNJI could raise the body's antioxidant function and the level of SOD and GSH-Px (P = 0.002, MD = 53.02, 95% CI: −20.52, 85.78; P = 0.01, MD = 8.65, 95% CI: 1.77, 15.48) and decrease the level of MDA (P < 0.00001, MD = −4.16, 95% CI: −5.50, −2.82).
Conclusion.
XNJI might be effective in cerebral ischemia by regulating oxidative stress and inflammatory reaction.
American Psychological Association (APA)
Ma, Rong& Ma, Xiao& Wen, Jianxia& Wang, Jian& Xie, Qian& Chen, Nian…[et al.]. 2018. Preclinical Evidence and Mechanism of Xingnaojing Injection for Cerebral Ischemia: A Systematic Review and Meta-Analysis of Animal Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156937
Modern Language Association (MLA)
Ma, Rong…[et al.]. Preclinical Evidence and Mechanism of Xingnaojing Injection for Cerebral Ischemia: A Systematic Review and Meta-Analysis of Animal Studies. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156937
American Medical Association (AMA)
Ma, Rong& Ma, Xiao& Wen, Jianxia& Wang, Jian& Xie, Qian& Chen, Nian…[et al.]. Preclinical Evidence and Mechanism of Xingnaojing Injection for Cerebral Ischemia: A Systematic Review and Meta-Analysis of Animal Studies. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156937