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Vaccinium macrocarpon Aiton Extract Ameliorates Inflammation and Hyperalgesia through Oxidative Stress Inhibition in Experimental Acute Pancreatitis
Joint Authors
Grespan, Renata
Hassimotto, Neuza Mariko Aymoto
Santana, Danielle G.
Camargo, Enilton A.
Oliveira, Alan Santos
Souza, Marília Trindade de Santana
Santos, José Thiago do Carmo
Silva, Ana Mara de Oliveira e
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We evaluated the effect of the hydroethanolic extract of fruits of Vaccinium macrocarpon (HEVm) in a model of acute pancreatitis (AP) in mice.
AP was induced by two injections of L-arginine and animals were treated with HEVm (50, 100, and 200 mg/kg, p.o.) or vehicle (saline) every 24 h, starting 1 h after the induction of AP.
Phytochemical analysis of the extract and measurement of inflammatory and oxidative stress parameters, as well as abdominal hyperalgesia, were performed.
Catechin, epicatechin, rutin, and anthocyanins were identified in HEVm.
Treatment with HEVm decreased L-arginine-induced abdominal hyperalgesia (from 48 to 72 h).
Also, treatment with HEVm decreased L-arginine-induced pancreatic edema, pancreatic and pulmonary neutrophil infiltration, and levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6, after 72 h of induction.
L-arginine-induced hyperamylasemia and hyperlipasemia were also reduced by the treatment with HEVm in comparison to vehicle-treated group.
Moreover, lipoperoxidation, carbonyl radicals, nonprotein sulfhydryl groups, and activity of catalase and superoxide dismutase, but not glutathione peroxidase, were restored by the treatment with HEVm.
These results show that treatment with HEVm decreased hyperalgesia and pancreatic/extrapancreatic inflammation and oxidative damage in L-arginine-induced AP, making this extract attractive for future approaches designed to treat this condition.
American Psychological Association (APA)
Santana, Danielle G.& Oliveira, Alan Santos& Souza, Marília Trindade de Santana& Santos, José Thiago do Carmo& Hassimotto, Neuza Mariko Aymoto& Silva, Ana Mara de Oliveira e…[et al.]. 2018. Vaccinium macrocarpon Aiton Extract Ameliorates Inflammation and Hyperalgesia through Oxidative Stress Inhibition in Experimental Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156940
Modern Language Association (MLA)
Santana, Danielle G.…[et al.]. Vaccinium macrocarpon Aiton Extract Ameliorates Inflammation and Hyperalgesia through Oxidative Stress Inhibition in Experimental Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156940
American Medical Association (AMA)
Santana, Danielle G.& Oliveira, Alan Santos& Souza, Marília Trindade de Santana& Santos, José Thiago do Carmo& Hassimotto, Neuza Mariko Aymoto& Silva, Ana Mara de Oliveira e…[et al.]. Vaccinium macrocarpon Aiton Extract Ameliorates Inflammation and Hyperalgesia through Oxidative Stress Inhibition in Experimental Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156940