Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Tetramethylpyrazine (TMP) is an alkaloid extracted from the root and stem of the traditional Chinese herbal medicine called Chuanxiong.
The present study aims to study the effects of TMP on hypoxic respiratory depression in rats.
Materials and methods.
The effects of TMP on respiratory responses of rats induced by hypoxia were observed by diaphragm electromyogram (EMG) recording.
The effects of TMP on the protein expression of FOS and acid sensing ion channel1a (ASIC1a) in the brainstem induced by hypoxia were investigated by immunohistochemistry.
Results.
The respiration of rats was first excited and then depressed during hypoxia treatment, while TMP pretreatment could significantly antagonize the respiratory depression induced by hypoxia P<0.01.
Hypoxia obviously induced the protein expression of FOS P<0.01 and ASIC1aP<0.05 in the brainstem, which can be also significantly inhibited by TMP pretreatment.
Conclusions.
TMP has protective effects on hypoxic respiratory depression, and the mechanisms might be concerned with its downregulation of FOS and ASIC1a in the brainstem induced by hypoxia.
American Psychological Association (APA)
Li, Li& Gao, Bo& Liu, Meifang. 2020. Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156947
Modern Language Association (MLA)
Li, Li…[et al.]. Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156947
American Medical Association (AMA)
Li, Li& Gao, Bo& Liu, Meifang. Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156947