Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats
Joint Authors
Woode, Eric
Benneh, Charles
Adongo, Donatus Wewura
Biney, Robert Peter
Ampadu, Felix Agyei
Tandoh, Augustine
Jato, Jonathan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Introduction.
The stem bark of Maerua angolensis DC.
(Capparaceae) is traditionally used for management of epilepsy.
Our aim was to evaluate the antiseizure potential and identify possible mechanisms by which the effects are registered.
Methods.
The petroleum ether/ethyl acetate extract (100–1000 mg kg−1) was administered per os to male Sprague-Dawley rats after pretreatment with flumazenil (0.3 mg kg−1) or L-arginine (150 mg kg−1) or sildenafil (5 mg kg−1) and they subsequently received a subcutaneous injection of pentylenetetrazole (65 mg kg−1).
Rats were observed for latency to and duration of myoclonic seizures and additionally the level of protection against oxidant markers and products was assessed in vitro and in vivo.
Results.
The extract (300 and 1000 mg kg−1, p.o.) significantly delayed the onset and decreased the duration and frequency of PTZ-induced convulsions.
The anticonvulsant effect of MAE (300 mg kg−1, p.o.) was reversed by pretreatment with flumazenil, L-arginine, or sildenafil.
Also, MAE (300 mg kg−1) treatment reversed significantly PTZ-induced oxidative stress in rat brain tissue.
Conclusion.
The petroleum ether/ethyl acetate fraction exhibits antiseizure activity by affecting GABAergic and nitric oxide-cGMP pathways.
In addition, the extract protects against the generation of free radicals and the oxidative products of the PTZ-induced seizures.
American Psychological Association (APA)
Benneh, Charles& Biney, Robert Peter& Tandoh, Augustine& Ampadu, Felix Agyei& Adongo, Donatus Wewura& Jato, Jonathan…[et al.]. 2018. Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156950
Modern Language Association (MLA)
Benneh, Charles…[et al.]. Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156950
American Medical Association (AMA)
Benneh, Charles& Biney, Robert Peter& Tandoh, Augustine& Ampadu, Felix Agyei& Adongo, Donatus Wewura& Jato, Jonathan…[et al.]. Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156950