Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation
Joint Authors
Sung, Jeehye
Hong, Sungwha
Kim, Younghwa
Lee, Hana
Heo, Huijin
Lee, Junsoo
Jeong, Heon Sang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed at evaluating the cytoprotective activity of jujube water extract (JWE) against alcohol-induced oxidative stress via the activation of the Nrf2 pathway in HepG2 cells.
JWE had various phenolic compounds, and the vanillic acid content was the highest in the extract.
To determine the cytoprotective effect of JWE against alcohol-induced damage, hepatocytes were treated with JWE and 3% ethanol.
JWE (100 μg/mL) markedly increased cell viability by approximately 100% in a dose-dependent manner.
Moreover, JWE attenuated the production of malondialdehyde, reactive oxygen species, aspartate, and alanine aminotransferase and the depletion of glutathione.
Moreover, JWE enhanced the expression of antioxidant defense enzymes including heme oxygenase-1, NADPH quinone oxidoreductase 1, and γ-glutamate-cysteine ligase catalytic against alcohol-induced oxidative damage in hepatocytes via the activation of Nrf2.
Taken together, JWE possesses the protective effect against alcohol-induced oxidative injury in hepatocytes through the upregulation of the Nrf2 signaling pathway.
Therefore, jujube fruit might have the potential to improve alcohol-related liver problems.
American Psychological Association (APA)
Hong, Sungwha& Kim, Younghwa& Sung, Jeehye& Lee, Hana& Heo, Huijin& Jeong, Heon Sang…[et al.]. 2020. Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1157031
Modern Language Association (MLA)
Hong, Sungwha…[et al.]. Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1157031
American Medical Association (AMA)
Hong, Sungwha& Kim, Younghwa& Sung, Jeehye& Lee, Hana& Heo, Huijin& Jeong, Heon Sang…[et al.]. Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1157031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157031