Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells
Joint Authors
Kim, Min Ji
Wang, Hye Soo
Lee, Min Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The fermentation was carried out on the bark of Acanthopanax sessiliflorus (AS).
Acanthopanax species have been used in traditional medicine as tonics, sedatives, and antispasmodics.
An activity-guided isolation of the fermented bark of A.
sessiliflorus (FAS) yielded several phytochemicals: acanthoside D (1), acanthoside B (2), daucosterol (3), protocatechuic acid (4), chlorogenic acid methyl ester (5), ciwujiatone (6), syringaresinol (7), farnesol (8), 3,4-dicaffeoylquinic acid (9), and falcarindiol (10).
HPLC analysis showed that content of lignan glycoside (1) was decreased and 4 and 7 were increased after fermentation.
Anti-inflammatory activities on FAS showed the decrease of nitric oxide (NO) production, and inhibitory activities of iNOS and COX-2, proinflammatory cytokines (IL-6 and tumor necrosis factor-α), and collagenase.
The aglycone, syringaresinol (7), which was increased through fermentation showed enhanced activity than 1.
Thus, FAS may have the potential to treat inflammatory disorders, such as arthritis.
American Psychological Association (APA)
Kim, Min Ji& Wang, Hye Soo& Lee, Min Won. 2020. Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157075
Modern Language Association (MLA)
Kim, Min Ji…[et al.]. Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157075
American Medical Association (AMA)
Kim, Min Ji& Wang, Hye Soo& Lee, Min Won. Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157075