Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial
Joint Authors
Xue, Jing-Xian
Bian, Wei-He
Yao, Chang
Ye, Bei
Liu, Shun
Cao, Si-han
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response.
Methods.
Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group.
The size of the neoplasm and pain score of patients were followed-up for 4 weeks.
Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits.
The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured.
Results.
After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs.
21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004).
Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α.
Conclusion.
External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation.
This trial is registered with ChiCTR1800017744.
American Psychological Association (APA)
Xue, Jing-Xian& Ye, Bei& Liu, Shun& Cao, Si-han& Bian, Wei-He& Yao, Chang. 2020. Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157134
Modern Language Association (MLA)
Xue, Jing-Xian…[et al.]. Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157134
American Medical Association (AMA)
Xue, Jing-Xian& Ye, Bei& Liu, Shun& Cao, Si-han& Bian, Wei-He& Yao, Chang. Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157134