Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo
Joint Authors
Hur, Haeng Jeon
Lee, Ae Sin
Lee, Sang Hee
Kim, So Ah
Sung, Mi Jeong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteoporosis is characterized by decreased bone mass and bone microarchitectural failure, leading to an enhanced risk of bone fractures.
Chrysanthemum coronarium L.
(CC) is a natural plant with powerful antioxidant activity.
This study investigated the antiosteoporotic effects of CC extracts in in vitro cell cultures and in vivo bone loss animal models.
CC stimulated osteoblast differentiation and mineralized bone formation by osteoblasts by increasing the expression of bone formation markers (alkaline phosphatase, osteoprotegerin, and osteoprotegerin/receptor activator nuclear factor-κB ligand ratio) in the murine preosteoblastic cell line MC3T3-E1.
Additionally, CC was found to inhibit osteoclast differentiation by downregulating bone resorption markers (tartrate-resistant acid phosphatase, cathepsin K, dendritic cell-specific transmembrane protein, and calcitonin receptor) in the murine macrophage-like cell line RAW264.7.
CC prevented ovariectomy-induced bone loss, preserved trabecular microarchitecture, and improved serum bone turnover markers in an osteoporotic mouse model.
These findings suggest that CC extract may be considered as a natural therapeutic or preventive agent for osteoporotic bone loss.
American Psychological Association (APA)
Kim, So Ah& Lee, Ae Sin& Hur, Haeng Jeon& Lee, Sang Hee& Sung, Mi Jeong. 2020. Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157135
Modern Language Association (MLA)
Kim, So Ah…[et al.]. Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157135
American Medical Association (AMA)
Kim, So Ah& Lee, Ae Sin& Hur, Haeng Jeon& Lee, Sang Hee& Sung, Mi Jeong. Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157135