Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation
Joint Authors
Liang, Yi
Zhou, You
Zhou, Jie
Jin, Ying
Ma, Ruijie
Song, Hongyun
Chen, Qin
Chai, Yueyang
Fang, Jian-Qiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Both experimental and clinical studies have shown that electroacupuncture (EA) administration ameliorates chronic inflammatory pain (CIP).
However, the multifaceted mechanism underlying the effects of EA on CIP is poorly understood.
In this study, the mRNA transcriptome was used to study various therapeutic targets of EA.
Methods.
Using RNA-sequencing, protein-coding mRNA expression profiles of the L4-L5 dorsal root ganglion (DRG) were examined in the control (CN), complete Freund’s adjuvant- (CFA-) induced CIP, and EA-treated CIP groups.
A series of bioinformatics analyses was performed; “EA-reversed upregulated genes with CIP” (up-DEGs) and “EA-reversed downregulated genes with CIP” (down-DEGs) were identified.
Thereafter, based on up-DEGs and down-DEGs, biological functions and signaling pathways were enriched using gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses.
Results.
In total, 189 DEGs were identified, including 134 up- and 55 down-DEGs, which were enriched in arachidonic acid metabolism (rno00590), glutamatergic synapse (rno04724), serotonergic synapse (rno04726), FoxO signaling pathway (rno04068), insulin signaling pathway (rno04910), amyotrophic lateral sclerosis (rno05014), cholinergic synapse (rno04725), ECM-receptor interaction (rno04512), and choline metabolism in cancer (rno05231).
Conclusion.
We identified a few GOs, pathways, and genes that could play key roles in the amelioration of CIP by EA.
Hence, this study may provide a theoretical basis for CIP amelioration by EA.
American Psychological Association (APA)
Zhou, Jie& Jin, Ying& Ma, Ruijie& Song, Hongyun& Chen, Qin& Chai, Yueyang…[et al.]. 2020. Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157162
Modern Language Association (MLA)
Zhou, Jie…[et al.]. Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157162
American Medical Association (AMA)
Zhou, Jie& Jin, Ying& Ma, Ruijie& Song, Hongyun& Chen, Qin& Chai, Yueyang…[et al.]. Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157162