Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action
Joint Authors
Ventura-Martinez, Rosa
Angeles-Lopez, Guadalupe Esther
Gonzalez-Trujano, Maria Eva
Carrasco, Omar F.
Deciga-Campos, Myrna
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tagetes lucida has been used in traditional medicine as a remedy to alleviate several gastrointestinal disorders that provoke stomachaches, abdominal cramps, and diarrhea.
However, there is not enough scientific evidence that supports these effects.
Therefore, the purpose of this study was to evaluate antispasmodic and antidiarrheal activities of aqueous extract of T.
lucida (AqExt-TL) as well as its mechanism of action in experimental models.
Antispasmodic activity and the mechanism of action of AqExt-TL were assessed on segments of the guinea pig ileum precontracted with KCl, acetylcholine (ACh), or electrical field stimulation (EFS).
Furthermore, the antispasmodic effect of two coumarins (umbelliferone and herniarin) previously identified in this species was evaluated.
Antidiarrheal activity of AqExt-TL was determined using the charcoal meal test in mice.
AqExt-TL showed antispasmodic activity in segments of the guinea pig ileum precontracted with KCl (83.7 ± 1.9%) and ACh (77.2 ± 5.3%) at the maximal concentration; however, practically, it did not alter the contractions induced by EFS (10.1 ± 2.2%).
Antispasmodic activity of AqExt-TL was not significantly altered by hexamethonium (a ganglionic blocker) or L-NAME (an inhibitor of nitric oxide synthase).
However, this extract decreased the maximal contractile response to calcium (82.7 ± 8.5%), serotonin (68.1 ± 8.5%), and histamine (63.9 ± 5.9%) in their concentration-response curves.
Umbelliferone and herniarin also induced an antispasmodic effect on tissues precontracted with KCl.
In addition, low doses of AqExt-TL reduced to 50% the distance traveled by charcoal meal in the gastrointestinal transit model in mice as loperamide, an antidiarrheal agent, did.
These results provided evidence of the antispasmodic and antidiarrheal activity of T.
lucida, which supports its use in the folk medicine in relieving symptoms in some gastrointestinal disorders.
In the antispasmodic effect, the blockade of histaminergic and serotoninergic pathway as well as the calcium channels seems to be involved.
Finally, umbelliferone and herniarin could be partially responsible for the antispasmodic activity induced by T.
lucida.
American Psychological Association (APA)
Ventura-Martinez, Rosa& Angeles-Lopez, Guadalupe Esther& Gonzalez-Trujano, Maria Eva& Carrasco, Omar F.& Deciga-Campos, Myrna. 2020. Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157171
Modern Language Association (MLA)
Ventura-Martinez, Rosa…[et al.]. Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157171
American Medical Association (AMA)
Ventura-Martinez, Rosa& Angeles-Lopez, Guadalupe Esther& Gonzalez-Trujano, Maria Eva& Carrasco, Omar F.& Deciga-Campos, Myrna. Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157171