Serum Metabolic Profiling Analysis of Gout Patients Treated with Traditional Chinese Medicine Tongfengtai Granules Based on Gas Chromatography-Mass Spectrometry
Joint Authors
Wang, Bin-Bin
Zhang, Jianyong
Xie, Jingjing
Qiu, Xia
Xiao, Yuya
Zhang, Yanying
Jia, Ertao
Pan, Hong
Wang, Jing
Wang, Ruyi
Zhong, Li
Li, Tengyan
Xiao, Min
Jiang, Yubao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Gout has become a public health problem that seriously threatens human health.
Traditional Chinese medicines (TCMs) have a long history of treating gout and have some advantages compared with the conventional medicines.
Compound TCM Tongfengtai granules are gradually being used for clinical treatment of gout, but its mechanism is still unclear.
The purpose of this study was to explore the metabolic profiling of serum from gout patients before and after treatment with Tongfengtai granules and identify the differential metabolites and related metabolic pathways.
A total of 40 gout patients hospitalized in Shenzhen Traditional Chinese Medicine Hospital from 2018 to March 2019 were recruited in the current study, and serum samples from these patients before and after treatment with Tongfengtai granules were collected.
Gas chromatography-mass spectrometry (GC-MS) assay was used to identify serum metabolites.
The OPLS-DA VIP method was used to screen for potential metabolic biomarkers, and MetaboAnalyst 4.0 was used to identify related metabolic pathways.
The result showed that there was a significant difference in the concentrations of six metabolites in the serum after treatment: D-galactose, lactic acid, 3-hydroxybutyric acid, D-pyran (type) glucose, alanine, and L-isoleucine.
Except D-pyran (type) glucose, the serum concentrations of the other five metabolites were all significantly reduced.
Besides, pathway enrichment analysis found that these potential metabolic biomarkers were mainly involved in lactose degradation and the glucose-alanine cycle.
Thus, the serum metabolic profiling of gout patients treated with Tongfengtai granules changed, and the differential metabolites and related metabolic pathways might provide clues for understanding the mechanism of Tongfengtai granules.
American Psychological Association (APA)
Zhang, Jianyong& Pan, Hong& Xie, Jingjing& Wang, Jing& Wang, Ruyi& Qiu, Xia…[et al.]. 2020. Serum Metabolic Profiling Analysis of Gout Patients Treated with Traditional Chinese Medicine Tongfengtai Granules Based on Gas Chromatography-Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157238
Modern Language Association (MLA)
Zhang, Jianyong…[et al.]. Serum Metabolic Profiling Analysis of Gout Patients Treated with Traditional Chinese Medicine Tongfengtai Granules Based on Gas Chromatography-Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1157238
American Medical Association (AMA)
Zhang, Jianyong& Pan, Hong& Xie, Jingjing& Wang, Jing& Wang, Ruyi& Qiu, Xia…[et al.]. Serum Metabolic Profiling Analysis of Gout Patients Treated with Traditional Chinese Medicine Tongfengtai Granules Based on Gas Chromatography-Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157238