Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
Joint Authors
Hongzhi, Wang
Zhou, Qing-bing
Zhu, Qian-zhe
Wang, De-xiu
Liu, Zheng-tang
Xu, Yong-gang
Hu, Xiao-mei
Ma, Rou
Xu, Feng-qin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aberrant hypermethylation and hypomethylation both play important roles in myelodysplastic syndrome (MDS).
Hypomethylating agents targeting hypermethylation have been employed for the MDS treatment, but the treatment effect is limited.
Novel drugs for DNA hypomethylation-targeted therapy may be needed to improve clinic efficacy for the treatment of MDS.
Chinese medicine (CM) herbs have been used to treat MDS for many years in our hospital.
However, the long-term treatment effect and mechanism remain unclear.
In this study, all 135 patients received CM treatment for at least 36 months.
The response rates for CM treatment were 81.53% (106/130) for hematological improvement in 130 MDS-RCMD patients and 80% (4/5) for bone marrow CR in 5 MDS-RAEB patients, respectively.
The Human Methylation 850K BeadChip showed that 115 genes (50.88%) were aberrantly hypomethylated in 5 MDS patients compared with 3 healthy individuals.
GO-analysis showed that these hypomethylated genes participated in many cancer-related biological functions and pathways.
Furthermore, 60 genes were hypermethylated and the protein expression level of DNMT1 was significantly increased in the 5 MDS patients after 6 months of CM treatment.
Our study suggests that CM can improve aberrant hypomethylation by increasing DNMT1 expression in MDS.
The data support the clinical application of CM herbs containing arsenic as an innovative hypermethylation-inducing regimen for the treatment of MDS.
American Psychological Association (APA)
Zhou, Qing-bing& Zhu, Qian-zhe& Hongzhi, Wang& Wang, De-xiu& Liu, Zheng-tang& Xu, Yong-gang…[et al.]. 2020. Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157253
Modern Language Association (MLA)
Zhou, Qing-bing…[et al.]. Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157253
American Medical Association (AMA)
Zhou, Qing-bing& Zhu, Qian-zhe& Hongzhi, Wang& Wang, De-xiu& Liu, Zheng-tang& Xu, Yong-gang…[et al.]. Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157253