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Anti-Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans
Joint Authors
Suthisamphat, Naranpraphai
Dechayont, Bhanuz
Phuaklee, Pathompong
Prajuabjinda, Onmanee
Vilaichone, Ratha-Korn
Itharat, Arunporn
Mokmued, Khwanchanok
Prommee, Nuntika
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aril (mace) of Myristica fragrans, known as Dok-Chan, is a spice that has long been used for treating stomach discomfort, peptic ulcer, and nausea.
It is an ingredient in many remedies in Thai traditional medicine, e.g., Ya-Hom-Thep-Bha-Jit, Ya-Hom-Nao-Wa-Kot, and Ya-That-Bun-Job, which are used to treat dyspepsia and other gastrointestinal tract symptoms.
The aqueous and ethanolic extracts of mace were used for all tests.
Anti-H.
pylori activities were determined by the disc diffusion method and agar dilution.
Anti-inflammatory activity was determined by the LPS-induced nitric oxide (NO) inhibition in a RAW264.7 cell line, and cytotoxicity was determined against gastric cancer cell lines (Kato III) using the sulphorhodamine B (SRB) assay.
The DPPH radical scavenging and ABTS radical cation decolorization assays were used to determine the antioxidant activities.
The result found that the ethanolic extract of mace exhibited antimicrobial activity against H.
pylori ATCC 43504 and six clinical strains with MIC values of 125–250 μg/ml.
The aqueous extract MICs against H.
pylori ATCC reference strain and six clinical strains were 500 μg/ml compared with 0.5 μg/ml for the positive control, clarithromycin.
The inhibitory effect of LPS-induced NO release and cytotoxic activity of the ethanolic extract had IC50 values of 82.19 μg/ml and 26.06 μg/ml, respectively, and the EC50 values for the DPPH and ABTS antioxidant assays were 13.41 μg/ml and 12.44 μg/ml, respectively.
The mace extract also had anticancer properties.
In conclusion, the ethanolic mace extract had anti-H.
pylori, anti-inflammatory, antioxidant, and anticancer activities.
These data support further preclinical and clinical investigation to see if the mace extract could have a role in treating patients with dyspepsia, peptic ulcers, and possibly gastric cancer.
American Psychological Association (APA)
Suthisamphat, Naranpraphai& Dechayont, Bhanuz& Phuaklee, Pathompong& Prajuabjinda, Onmanee& Vilaichone, Ratha-Korn& Itharat, Arunporn…[et al.]. 2020. Anti-Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1157304
Modern Language Association (MLA)
Suthisamphat, Naranpraphai…[et al.]. Anti-Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1157304
American Medical Association (AMA)
Suthisamphat, Naranpraphai& Dechayont, Bhanuz& Phuaklee, Pathompong& Prajuabjinda, Onmanee& Vilaichone, Ratha-Korn& Itharat, Arunporn…[et al.]. Anti-Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1157304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157304