Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Joint Authors
Chen, Zhe
Huang, Ying
Wang, Hui
Shen, Pan
Huang, Yao
Ba, Xin
Qin, Kai
Lin, Weiji
Tu, Shenghao
Wang, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
The aim of this review and meta-analysis was to assess the effects and safety of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis.
Design.
A systematic literature search was carried out in eight databases from their available dates of inception to April 2020.
After screening, fifteen randomized, controlled trials (RCTs) comparing the effects and safety of mSMP in combination with western medicine (including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs)) in treating rheumatoid arthritis patients were included after screening.
Results.
In comparison with DMARDs, or coadministration of DMARDs and NSAIDs, mSMP in combination with western medicine significantly lowered erythrocyte sedimentation rate (mean difference (MD) = -10.61, 95% confidence interval (CI) [−12.19, −9.03]), C-reactive protein (MD = −6.50, 95% CI [−8.43, −4.56]), rheumatoid factors (MD = −17.31, 95% CI [−24.34, −10.27]), swollen joint count (MD = −1.63, 95% CI [−2.29, −0.97]), tender joint count (MD = −1.98, 95% CI [−2.34, −1.62]), and morning stiffness time (MD = −24.37, 95% CI [−29.41, 19.33]) and ameliorated the condition of patients (odds ratio (OR) = 3.69, 95% CI [2.64, 5.14]).
Additionally, mSMP in combination with western medicine seemed safer (OR = 0.49, 95% CI [0.30, 0.81]).
Conclusion.
The results of the meta-analysis study have shown that mSMP in combination with western medicine therapies appears to be more effective and safer than western medicine alone in the treatment of rheumatoid arthritis including reducing inflammatory markers and adverse events and improving symptoms.
Howbeit, more high-grade, large-scale RCTs of mSMP in various countries and regions are still needed.
American Psychological Association (APA)
Wang, Hui& Huang, Yao& Shen, Pan& Wang, Yu& Qin, Kai& Huang, Ying…[et al.]. 2020. Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157326
Modern Language Association (MLA)
Wang, Hui…[et al.]. Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157326
American Medical Association (AMA)
Wang, Hui& Huang, Yao& Shen, Pan& Wang, Yu& Qin, Kai& Huang, Ying…[et al.]. Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157326