Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review
Joint Authors
Chen, Shujiao
Lin, Xuejuan
Zhang, Ping
Asakawa, Tetsuya
Xia, Shujie
Gao, Bizhen
Chai, Yujuan
Li, Candong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Qi-replenishing Chinese medicines (QCMs) are used for treating prediabetes in the traditional Chinese medicine (TCM) clinical practice.
The aims of this meta-analysis were to (i) verify the efficacy and safety of QCMs in treating prediabetes and (ii) investigate the clinical outcomes between the trials complying with and not complying with the principle of “syndrome differentiation.” Methods.
We included only randomized controlled clinical trials (RCTs) whose Jadad scores were not less than 4.
The overall clinical outcomes, including the incidence rate of diabetes, normalization of blood glucose, changes in fasting blood glucose (FBG), 2 h postprandial blood glucose, HbA1c, and occurrence of adverse events, were evaluated.
Subgroup analyses were performed.
Results.
A total of 11 RCTs that enrolled 2210 patients with prediabetes were included.
We observed that overall treatment with QCMs significantly ameliorated the clinical outcomes of prediabetes without increasing incidence of adverse events.
The results of subgroup analyses revealed that prescribing QCMs complying with syndrome differentiation ameliorated all the clinical indices, whereas prescribing not complying with syndrome differentiation could not achieve significant amelioration in FBG and HbA1c levels.
Furthermore, the subgroup with syndrome differentiation reported more adverse events.
Conclusions.
The overall results suggested that QCMs are effective and safe in treating prediabetes.
Results of subgroup analyses indicated that the groups with syndrome differentiation presented better efficacy but had a higher occurrence of adverse events.
This study indicated the important role of the principle of syndrome differentiation in TCM and that the adverse events of QCMs cannot be ignored in TCM clinical practice.
American Psychological Association (APA)
Xia, Shujie& Gao, Bizhen& Chen, Shujiao& Lin, Xuejuan& Zhang, Ping& Chai, Yujuan…[et al.]. 2020. Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1157328
Modern Language Association (MLA)
Xia, Shujie…[et al.]. Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1157328
American Medical Association (AMA)
Xia, Shujie& Gao, Bizhen& Chen, Shujiao& Lin, Xuejuan& Zhang, Ping& Chai, Yujuan…[et al.]. Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1157328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157328