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Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer's Disease
Joint Authors
Zhang, Xinyue
Li, Hongxing
Gu, Lili
Wu, Ningzi
Zhang, Lingxi
Lu, Jiaqi
Li, Qin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aims to explore the possible homologous mechanism of 7 frequently‐used herbs for heat-clearing and detoxification in traditional Chinese medicine (HDTCM) for treating Alzheimer's disease (AD), one of the most common types of dementia, based on network pharmacology.
Herbs that satisfied the criteria of containing chlorogenic acid, relating to AD and aligning with HDTCM, were simultaneously collected to determine whether they have anti-AD effect based on a survey of the literature.
Herb-ingredient-target-disease networks were constructed by collecting information from the TCMSP and GeneCards public databases.
The common targets of the herbs and AD were identified for conducting a Gene Ontology (GO) analyses and a Reactome pathway enrichment analysis.
The results showed that PTGS1, IL-6, CASP3, and VEGFA were the predicted key gene targets.
The IL-4 and IL-13 signaling pathway, the ESR-mediated signaling pathway, and the extranuclear estrogen signaling pathway were the significant pathways associated with the 7 herbs.
This study revealed that the analogous anti-AD mechanism of the 7 herbs of HDTCM may be associated with anti-inflammation, which is a common effect of the chlorogenic acid and quercetin components.
American Psychological Association (APA)
Li, Hongxing& Zhang, Xinyue& Gu, Lili& Wu, Ningzi& Zhang, Lingxi& Lu, Jiaqi…[et al.]. 2020. Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157347
Modern Language Association (MLA)
Li, Hongxing…[et al.]. Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157347
American Medical Association (AMA)
Li, Hongxing& Zhang, Xinyue& Gu, Lili& Wu, Ningzi& Zhang, Lingxi& Lu, Jiaqi…[et al.]. Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157347