Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology
Joint Authors
Xie, Guanqun
Yang, Zi
Xie, Rui-fei
Zhong, Min-hong
Fan, Yong-sheng
Zhao, Ting
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a refractory autoimmune disease.
Zhibai Dihuang Wan (ZDW) has frequently been used for treating SLE in China and been proved to have a prominent role in decreasing SLE patients’ morality rate.
However, the active substances in ZDW and the molecular mechanisms of ZDW in SLE remain unclear.
This study identified the bioactive compounds and delineated the molecular targets and potential pathways of ZDW by using a network biology approach.
First, we collected putative targets of ZDW based on TCMSP, GeneCards, and STITCH databases and built a network containing the interactions between the putative targets of ZDW and known therapeutic targets of SLE.
Then, the key hubs were imported to DAVID Bioinformatics Resources 6.7 to perform gene ontology biological process (GOBP) and pathway enrichment analysis.
A total of 95 nodes including 73 putative targets of ZDW were determined as major hubs in terms of their node degree.
The results of GOBP and pathway enrichment analysis indicated that putative targets of ZDW mostly were involved in various pathways associated with inflammatory response and apoptosis.
More importantly, eleven putative targets of ZDW (CASP3, BCL2, BAX, CYCS, NFKB1, NFKBIA, IL-6, IL-1β, PTGS2, CCL2, and TNF-α) were recognized as active factors involved in the main biological functions of treatment, implying the underlying mechanisms of ZDW acting on SLE.
This study provides novel insights into the mechanisms of ZDW in SLE, from the molecular level to the pathway level.
American Psychological Association (APA)
Yang, Zi& Xie, Rui-fei& Zhong, Min-hong& Xie, Guanqun& Fan, Yong-sheng& Zhao, Ting. 2020. Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157352
Modern Language Association (MLA)
Yang, Zi…[et al.]. Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157352
American Medical Association (AMA)
Yang, Zi& Xie, Rui-fei& Zhong, Min-hong& Xie, Guanqun& Fan, Yong-sheng& Zhao, Ting. Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157352