Huoxin Pill Attenuates Cardiac Inflammation by Suppression of TLR4NF-κB in Acute Myocardial Ischemia Injury Rats
Joint Authors
Chu, Jian-Feng
Shen, Aling
Chen, Youqin
Peng, Jun
Zhou, Xueling
Peng, Meizhong
Lu, Yan
Farman, Ali
Peng, Lianli
Gao, Huajian
Li, Qi
Chen, Xintong
Xie, Lingling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Huoxin Pill (HXP), a traditional Chinese medicine, has been prescribed widely in the treatment of coronary heart disease, angina pectoris, and other diseases.
However, the possible protective mechanisms of HXP on myocardial ischemia remain unclear.
In the current study, we investigated the effects and potential mechanism of HXP on myocardial ischemia and cardiac inflammation and the activation of TLR4/NF-κB pathway.
Determination of electrocardiogram, echocardiography, and heart weight index (HWI) indicated that HXP treatment obviously attenuated the elevation of ST-segment, end-diastolic volume, and HWI in the AMI rat model.
Enzyme-linked immunosorbent assay (ELISA) demonstrated that Huoxin Pill treatment significantly decreased the levels of CTnT, CK-MB, MDA, IL-6, and TNF-α, while it increased SOD content in serum of the AMI rat model.
Moreover, hematoxylin and eosin (HE) and immunohistochemistry (IHC) staining revealed that HXP treatment alleviated pathological change, infiltration of inflammatory cells, levels of IL-6 and TNF-α, and expression of TLR4 and p-NF-κB in cardiac tissues of the AMI rat model.
In conclusion, HXP treatment significantly improves cardiac function and attenuates cardiac inflammation by suppressing the activation of TLR4/NF-κB pathway in the ISO-induced AMI rat model.
This study provides insights into the potential of HXP on prevention and treatment of AMI.
American Psychological Association (APA)
Chu, Jian-Feng& Zhou, Xueling& Peng, Meizhong& Lu, Yan& Farman, Ali& Peng, Lianli…[et al.]. 2020. Huoxin Pill Attenuates Cardiac Inflammation by Suppression of TLR4NF-κB in Acute Myocardial Ischemia Injury Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157358
Modern Language Association (MLA)
Chu, Jian-Feng…[et al.]. Huoxin Pill Attenuates Cardiac Inflammation by Suppression of TLR4NF-κB in Acute Myocardial Ischemia Injury Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157358
American Medical Association (AMA)
Chu, Jian-Feng& Zhou, Xueling& Peng, Meizhong& Lu, Yan& Farman, Ali& Peng, Lianli…[et al.]. Huoxin Pill Attenuates Cardiac Inflammation by Suppression of TLR4NF-κB in Acute Myocardial Ischemia Injury Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157358