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Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model
Joint Authors
Kim, Mi Ran
Kim, Hyun Jin
Yu, Su Hyun
Lee, Bo Su
Jeon, Se Yeong
Lee, Jeong Jun
Lee, Young Chul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Red clover and hops are already known for their alternative menopausal therapies; however, their combination has not yet been studied.
This study aimed to evaluate the efficacy of the combination of red clover and hops extract (RHEC) for treating menopausal symptoms for the first time.
A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover extract and xanthohumol in hops extract.
An in vivo study was conducted using an ovariectomized rat model treated with RHEC (125, 250, and 500 mg/kg, p.o.) for a 12-week test period.
Changes in body weight, tail skin temperature (TST), serum lipid profile, bone metabolism, antioxidants, and markers of vasorelaxation and uterus endometrium were evaluated.
RHEC significantly inhibited body weight gain and decreased fat weight.
Changes in TST associated with flashes were significantly inhibited in the RHEC groups.
Other markers related to menopausal symptoms, such as blood lipid profile (total cholesterol and low-density-lipoprotein cholesterol), bone metabolism (serum alkaline phosphatase, osteocalcin, and c-terminal telopeptide type 1), antioxidants (superoxide dismutase and malondialdehyde), and vasorelaxants (endothelin-1 and nitric oxide), were significantly improved after the administration of RHEC.
We also confirmed the safety of RHEC through histopathological observation of the endometrium.
Our findings demonstrate that RHEC appears to have high potential for comprehensively improving various symptoms of menopause.
American Psychological Association (APA)
Kim, Mi Ran& Kim, Hyun Jin& Yu, Su Hyun& Lee, Bo Su& Jeon, Se Yeong& Lee, Jeong Jun…[et al.]. 2020. Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157367
Modern Language Association (MLA)
Kim, Mi Ran…[et al.]. Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157367
American Medical Association (AMA)
Kim, Mi Ran& Kim, Hyun Jin& Yu, Su Hyun& Lee, Bo Su& Jeon, Se Yeong& Lee, Jeong Jun…[et al.]. Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157367