![](/images/graphics-bg.png)
Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL6J Mice with High-Fat Diet-Induced Hyperlipidemia
Joint Authors
Liu, Yi-Hui
Xiang, Zhi-Nan
Wan, Luo-Sheng
Chen, Jia-Chun
Chen, Chen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this study, C57BL/6J mice with high-fat diet- (HFD-) induced hyperlipidemia were treated with total Liriope spicata var.
prolifera polysaccharides (TLSP: 200, 400, and 800 mg/kg body weight), simvastatin (3 mg/kg body weight), or saline for 8 weeks, respectively.
The results showed that TLSP had strong lipid-lowering and hepatoprotective effects on C57BL/6J mice with HFD-induced hyperlipidemia.
TLSP administration significantly reduced serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and downregulated the expressions of peroxisome proliferator-activated receptor (PPAR)γ and fatty acid synthase (FAS) in the adipose and liver tissues of the mice.
TLSP exerted hypolipidemic and hepatoprotective effects by activating lipid/bile acid metabolism via the FXH-SHP/CYP7A1 and SEBP-1c/FAC/ACC signaling pathways.
Thus, TLPS is a promising natural polymer with hepatoprotective and hypolipidemic properties.
American Psychological Association (APA)
Liu, Yi-Hui& Xiang, Zhi-Nan& Chen, Chen& Wan, Luo-Sheng& Chen, Jia-Chun. 2020. Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL6J Mice with High-Fat Diet-Induced Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157380
Modern Language Association (MLA)
Liu, Yi-Hui…[et al.]. Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL6J Mice with High-Fat Diet-Induced Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157380
American Medical Association (AMA)
Liu, Yi-Hui& Xiang, Zhi-Nan& Chen, Chen& Wan, Luo-Sheng& Chen, Jia-Chun. Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL6J Mice with High-Fat Diet-Induced Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157380