Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine
Joint Authors
Lin, Fei
Chen, Heng-Wen
He, Xuan-Hui
Liu, Chao
Zhao, Guoan
Sun, Siyu
Li, Yan
Liang, Wan-Qian
Shi, Zhuo-Lin
Tian, Pan-Pan
Huang, Ming-Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There has been an increase in morbidity and mortality related to coronary heart disease (CHD) in China in recent years.
Numerous clinical experiences and studies have shown that traditional Chinese medicine (TCM) plays an important role in the prevention, treatment, and prognosis of CHD.
However, the mechanism of TCM in the treatment of CHD has not yet been elucidated.
The circRNA-miRNA-mRNA network consists of miRNA that is competitively bound by circRNA, and miRNA regulates the transcription level of mRNA.
Through literature review, we found that the circRNA-miRNA-mRNA network acts to contribute to certain effects to CHD such as myocardial hypertrophy, myocardial fibrosis, and heart failure.
TCM contains constituents that act against CHD by antiatherosclerosis and apoptosis inhibition action, cardiac and cardiomyocyte protection, and these components also promote cell growth and protection of the vascular system by regulating miRNAs.
Therefore, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for the effective treatment of CHD by TCM.
American Psychological Association (APA)
Lin, Fei& Chen, Heng-Wen& Zhao, Guoan& Li, Yan& He, Xuan-Hui& Liang, Wan-Qian…[et al.]. 2020. Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157387
Modern Language Association (MLA)
Lin, Fei…[et al.]. Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157387
American Medical Association (AMA)
Lin, Fei& Chen, Heng-Wen& Zhao, Guoan& Li, Yan& He, Xuan-Hui& Liang, Wan-Qian…[et al.]. Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157387