Lycium Berry Polysaccharides Strengthen Gut Microenvironment and Modulate Gut Microbiota of the Mice
Joint Authors
Xia, Wenrui
Li, Xiaoang
Su, Lu
Leong, Wai Kit
Yin, Lin
Bian, Xiqing
Su, Jiyan
Khan, Imran
Hsiao, W. L. Wendy
Huang, Guoxin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lycium barbarum polysaccharides (LBP) are the main active components of Lycium barbarum with many cited health effects.
We hypothesize that gut microbiota and their metabolites might contribute to the health benefits of LBP.
To test this hypothesis, C57BL/6J mice were gavaged with LBP, and the impact on the gut microbiota was investigated.
The results showed that LBP facilitates the shifting of the epithelial immunity from the pro- to the anti-inflammatory microenvironment.
We further showed a significant reduction of the potentially pathogenic bacteria in mice treated with LBP based on the 16S sequencing of mouse fecal DNAs.
Importantly, LBP treatment enriched the xylan/fiber degrading bacteria and the short-chain fatty acids– (SCFAs-) producing bacteria.
Associated with the treatment was the increase of serum SCFAs detected by UHPLC-QTOF/MS analysis as well as the upregulation of the SCFA-sensing receptors, GPRs 41, 43, and 109a.
These findings strongly suggest that the health benefits of LBP might act through the modulation of gut microbiota.
American Psychological Association (APA)
Xia, Wenrui& Li, Xiaoang& Khan, Imran& Yin, Lin& Su, Lu& Leong, Wai Kit…[et al.]. 2020. Lycium Berry Polysaccharides Strengthen Gut Microenvironment and Modulate Gut Microbiota of the Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157403
Modern Language Association (MLA)
Xia, Wenrui…[et al.]. Lycium Berry Polysaccharides Strengthen Gut Microenvironment and Modulate Gut Microbiota of the Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157403
American Medical Association (AMA)
Xia, Wenrui& Li, Xiaoang& Khan, Imran& Yin, Lin& Su, Lu& Leong, Wai Kit…[et al.]. Lycium Berry Polysaccharides Strengthen Gut Microenvironment and Modulate Gut Microbiota of the Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157403