The Effect of High-Frequency Electrical Stimulation of Bilateral Nucleus Accumbens on the Behavior of Morphine-Induced Conditioned Place Preference Rats at Extinction and Reinstatement Phases
Joint Authors
Yang, Chunhui
Qiu, Yiqing
Hu, Xiaowu
Chen, Jianchun
Wu, Yina
Wu, Xi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To explore the optimal time points for deep brain stimulation (DBS) on the treatment of morphine addiction and its possible mechanisms by investigating how high-frequency stimulation (HFS) in bilateral nucleus accumbens (NAc) at different time points influences the addictive behaviors of rats with drug addiction.
Methods.
The rats were randomly divided into extinction stimulation group (n = 20) and postextinction stimulation group (n = 20).
Ten rats in the extinction stimulation group were treated using 120 Hz HFS during extinction stage while another 10 rats with pseudostimulation were served as control group.
The CPP scores were evaluated at the second day after intervention, with total 9 sections accomplished.
The CPP scores were evaluated at the second day of the intervention.
In the postextinction stimulation group, 120 Hz HFS was intervened during the postextinction stage in 10 experimental rats and pseudostimulation was performed in 10 control rats.
Stimulation was performed for 7 days continuously, and a small dose of morphine was administrated to induce relapse after the postextinction period.
Results.
During the extinction phase, CPP scores after HFS were significantly higher.
During the postextinction phase, relapse CPP scores after HFS were dramatically lower.
Conclusion.
HFS of bilateral NAc inhibits the extinction of addictive behavior during the extinction phase, and HFS during the postextinction period suppresses relapse of drug seeking behavior.
American Psychological Association (APA)
Yang, Chunhui& Qiu, Yiqing& Hu, Xiaowu& Chen, Jianchun& Wu, Yina& Wu, Xi. 2020. The Effect of High-Frequency Electrical Stimulation of Bilateral Nucleus Accumbens on the Behavior of Morphine-Induced Conditioned Place Preference Rats at Extinction and Reinstatement Phases. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1157466
Modern Language Association (MLA)
Yang, Chunhui…[et al.]. The Effect of High-Frequency Electrical Stimulation of Bilateral Nucleus Accumbens on the Behavior of Morphine-Induced Conditioned Place Preference Rats at Extinction and Reinstatement Phases. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1157466
American Medical Association (AMA)
Yang, Chunhui& Qiu, Yiqing& Hu, Xiaowu& Chen, Jianchun& Wu, Yina& Wu, Xi. The Effect of High-Frequency Electrical Stimulation of Bilateral Nucleus Accumbens on the Behavior of Morphine-Induced Conditioned Place Preference Rats at Extinction and Reinstatement Phases. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1157466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157466