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Acidic Phospholipase A2-Peptide Derivative Modulates Oxidative Status and Microstructural Reorganization of Scar Tissue after Cutaneous Injury
Joint Authors
Chávez-Olórtegui, Carlos
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
García, Estefanny Ruiz
Barros, Edvaldo
Stransky, Stephanie
Freitas, Mariella Bontempo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
From in vitro and in vivo models, the proliferative and healing potential of an acidic phospholipase A2 (LAPLA2) from Lachesis muta venom was investigated.
The LAPLA2 proliferative activity was evaluated on fibroblasts and keratinocytes cultured, and the antioxidant and regenerative potential of LAPLA2 was analyzed in a murine model.
The animal study consisted of four groups: C (negative control): 0.9% NaCl; SS (positive control): 1% silver sulfadiazine; L1 group: 0.5% LAPLA2; and L2 group: 0.25% LAPLA2.
Wounds were topically treated daily for 12 days, and scar tissue samples were collected every 4 days.
In vitro, LAPLA2 stimulated marked time-dependent cell proliferation.
In vivo, it increased the antioxidant activity of superoxide dismutase (SOD) and catalase (CAT) and decreased malondialdehyde (MDA) and carbonyl protein (CP) levels in scar tissue treated with LAPLA2 at 0.5%.
This peptide was effective in stimulating cellular proliferation, neoangiogenesis, type I and III collagen deposition, and maturation in a time-dependent-way, reducing the time required for wound closure.
Our results indicated that LAPLA2 presented a remarkable potential in improving the oxidative status and microstructural reorganization of the scar tissue by stimulation of cellularity, angiogenesis, colagenogenesis, and wound contraction, suggesting that the peptide could be a potential candidate for a new healing drug.
American Psychological Association (APA)
García, Estefanny Ruiz& Barros, Edvaldo& Stransky, Stephanie& Chávez-Olórtegui, Carlos& Freitas, Mariella Bontempo& Novaes, Rômulo Dias…[et al.]. 2020. Acidic Phospholipase A2-Peptide Derivative Modulates Oxidative Status and Microstructural Reorganization of Scar Tissue after Cutaneous Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157476
Modern Language Association (MLA)
García, Estefanny Ruiz…[et al.]. Acidic Phospholipase A2-Peptide Derivative Modulates Oxidative Status and Microstructural Reorganization of Scar Tissue after Cutaneous Injury. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1157476
American Medical Association (AMA)
García, Estefanny Ruiz& Barros, Edvaldo& Stransky, Stephanie& Chávez-Olórtegui, Carlos& Freitas, Mariella Bontempo& Novaes, Rômulo Dias…[et al.]. Acidic Phospholipase A2-Peptide Derivative Modulates Oxidative Status and Microstructural Reorganization of Scar Tissue after Cutaneous Injury. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157476