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Efficacy of Acupuncture and Moxibustion as a Subsequent Treatment after Second-Line Chemotherapy in Advanced Gastric Cancer
Joint Authors
Zhang, Yong-jie
Min, Qi
Huang, Ying
Liu, Huai-dong
Zhu, Zi-yuan
Jiang, Fu-jin
Hua, Hai-qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To explore whether acupuncture and moxibustion can prevent disease progression of advanced gastric cancer patients completing second-line chemotherapy and, if so, the related mechanism.
Method.
Progression-free survival (PFS) and overall survival (OS) were main outcome measures.
The real-time quantitative PCR was used to detect the expression of genes including T-bet, IFN-γ, GATA3, and IL-4 in peripheral blood mononuclear cells (PBMCs).
IL-4, IL-6, Ca199, CRP, and IFN-γ in plasma levels were checked.
Results.
170 patients were randomly assigned in a 3 : 2 ratio to receive either acupuncture and moxibustion or sham acupuncture until progression.
135 patients were included in the primary analysis.
Both PFS and OS in treatment group were proven to be better than control group.
Acupuncture and moxibustion promoted typical Th1 cells drifting, as confirmed by increased T-bet/IFN-γ and decreased GATA3/IL-4 in mRNA levels from PBMCs, as well as upregulating IFN-γ and downregulating IL-4 in plasma levels.
IL-6, Ca199, and CRP in plasma levels were also reduced by acupuncture and moxibustion.
Conclusions.
Acupuncture and moxibustion can prolong PFS and OS of advanced gastric cancer patients completing second-line chemotherapy by reversing Th1/Th2 shift and attenuating inflammatory responses.
American Psychological Association (APA)
Zhang, Yong-jie& Min, Qi& Huang, Ying& Liu, Huai-dong& Zhu, Zi-yuan& Jiang, Fu-jin…[et al.]. 2020. Efficacy of Acupuncture and Moxibustion as a Subsequent Treatment after Second-Line Chemotherapy in Advanced Gastric Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157478
Modern Language Association (MLA)
Zhang, Yong-jie…[et al.]. Efficacy of Acupuncture and Moxibustion as a Subsequent Treatment after Second-Line Chemotherapy in Advanced Gastric Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157478
American Medical Association (AMA)
Zhang, Yong-jie& Min, Qi& Huang, Ying& Liu, Huai-dong& Zhu, Zi-yuan& Jiang, Fu-jin…[et al.]. Efficacy of Acupuncture and Moxibustion as a Subsequent Treatment after Second-Line Chemotherapy in Advanced Gastric Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157478