An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention
Joint Authors
Li, Yang
Han, Dong-Feng
Xu, Hui-Ying
Li, Rong-Hang
Zhao, Ding
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Osteoarthritis (OA) is one of the most common degenerative joint diseases that affects millions of people worldwide, mainly the aging population.
Despite numerous published reports, little is known about the pathology of this disease, and no feasible treatment plan exists to stop OA progression.
Recently, extensive basic and clinical studies have shown that adipokines play a key role in OA development.
Moreover, some drugs associated with adipokines have shown chondroprotective and anti-inflammatory effects on OA.
Visfatin has been shown to play a detrimental role in the progression of OA.
It increases the production of matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), induces the production of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, affects the differentiation of mesenchymal stem cells to adipocytes, and induces osteophyte formation by inhibiting osteoclastogenesis.
Although some side effects of chemical visfatin inhibitors have been reported, they were shown to be successful in the treatment of diabetes, cancer, and other diseases that can utilize Chinese herbs, further suggesting that similar therapeutic strategies could be used in OA prevention and treatment.
Here, we describe the pathophysiological mechanism of visfatin in OA and discuss some potential pharmacological interventions using Chinese herbs.
American Psychological Association (APA)
Han, Dong-Feng& Li, Yang& Xu, Hui-Ying& Li, Rong-Hang& Zhao, Ding. 2020. An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157479
Modern Language Association (MLA)
Han, Dong-Feng…[et al.]. An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1157479
American Medical Association (AMA)
Han, Dong-Feng& Li, Yang& Xu, Hui-Ying& Li, Rong-Hang& Zhao, Ding. An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157479