Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice
Joint Authors
Huang, Chi-Chang
Chen, Wen-Chyuan
Chen, Yi-Ming
Li, Huashuai
Chiu, Yen-Shuo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It has been reported that abundant nitric oxide content in endothelial cells can increase exercise performance.
The purpose of this study was to evaluate the potential beneficial effects of a combined extract comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG) on nitric oxide content to decrease exercise fatigue.
Male ICR (Institute of Cancer Research) mice were randomly divided into 4 groups and orally administered LVFG for 4 weeks.
The 4-week LVFG supplementation significantly increased serum nitric oxide content in the LVFG-1X and LVFG-2X groups.
Antifatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming test, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after an acute swimming exercise.
LVFG supplementation dose-dependently improved exercise performance and nitric oxide content, and it dose-dependently decreased serum ammonia and CK activity after exhaustive swimming test.
LVFG’s antifatigue properties appear to manifest by preserving energy storage (as blood glucose) and increasing nitric oxide content.
Taken together, our results show that LVFG could have the potential for alleviating physical fatigue due to its pharmacological effect of increasing serum nitric oxide content.
American Psychological Association (APA)
Chen, Yi-Ming& Li, Huashuai& Chiu, Yen-Shuo& Huang, Chi-Chang& Chen, Wen-Chyuan. 2020. Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157491
Modern Language Association (MLA)
Chen, Yi-Ming…[et al.]. Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157491
American Medical Association (AMA)
Chen, Yi-Ming& Li, Huashuai& Chiu, Yen-Shuo& Huang, Chi-Chang& Chen, Wen-Chyuan. Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157491