Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MSMS Method
Joint Authors
Source
International Journal of Analytical Chemistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Benzoylpaeoniflorin (BP) is a potential therapeutic agent against oxidative stress related Alzheimer’s disease.
In this study, a more rapid, selective, and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to determine BP in rat plasma distinguishing with a monoterpene isomer, benzoylalbiflorin (BA).
The method showed a linear response from 1 to 1000 ng/mL (r>0.9950).
The precision of the interday and intraday ranged from 2.03 to 12.48% and the accuracy values ranged from −8.00 to 10.33%.
Each running of the method could be finished in 4 minutes.
The LC-MS/MS method was validated for specificity, linearity, precision, accuracy, recovery, and stability and was found to be acceptable for bioanalytical application.
Finally, this fully validated method was successfully applied to a pharmacokinetic study in rats following oral administration.
American Psychological Association (APA)
Zhou, Chuanqi& Wang, Xiaoke. 2017. Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MSMS Method. International Journal of Analytical Chemistry،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1157494
Modern Language Association (MLA)
Zhou, Chuanqi& Wang, Xiaoke. Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MSMS Method. International Journal of Analytical Chemistry No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1157494
American Medical Association (AMA)
Zhou, Chuanqi& Wang, Xiaoke. Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MSMS Method. International Journal of Analytical Chemistry. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1157494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157494