Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis
Joint Authors
Wu, Shuang
Liu, FengZhi
Zhou, Dongrui
Xie, Liandi
Zhang, Shuangshuang
Liu, Ruijia
Zhu, Lingqun
Wang, Yao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Western medicine (WM) has certain limitations in terms of treating acute cerebral infarction (ACI), while tonic traditional Chinese medicine injections (TCMIs) have been shown to have obvious clinical effects as an adjunct to WM for ACI.
However, most randomized controlled trials (RCTs) to date have not performed direct comparisons of efficacy among tonic TCMIs.
This study designed a Bayesian network meta-analysis (NMA) to explore the therapeutic effect of tonic TCMIs on ACI.
A comprehensive search of RCTs of TCMIs combined with WM for ACI was conducted using electronic databases for studies dated from the start date of each database until February 2020.
Stata 13.0 and ADDIS 1.16.7 software were used to plot and analyze the data.
Sixty-six RCTs with a total of 5,989 patients involving 7 kinds of tonic TCMIs were included.
Among TCMIs, Shenfu injection (SFI) + WM ranked first in terms of improving clinical efficacy and the activities of daily living (ADLs) rating and reducing interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels.
While Ciwujia injection (CI) + WM was the best choice for reducing neurological impairment and the high-cut viscosity of whole blood (HCV).
Shenmai injection (SI) + WM had the greatest effects in terms of decreasing the levels of low-cut viscosity of whole blood (LCV), fibrinogen (FIB), and plasma viscosity (PV).
Based on the cluster analysis of the clinical efficacy and the neurological impairment, CI + WM and Shenqifuzheng (SQI) + WM were the best options for treating ACI.
With respect to adverse drug reactions (ADRs), 35 RCTs did not monitor ADRs during treatment.
In conclusion, tonic TCMIs could assist WM in benefiting patients with ACI.
However, due to the limitations of the current study, strict monitoring of ADRs and data from high-quality RCTs will be required in future to verify the advantage of TCMIs.
American Psychological Association (APA)
Zhou, Dongrui& Xie, Liandi& Wang, Yao& Wu, Shuang& Liu, FengZhi& Zhang, Shuangshuang…[et al.]. 2020. Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157497
Modern Language Association (MLA)
Zhou, Dongrui…[et al.]. Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157497
American Medical Association (AMA)
Zhou, Dongrui& Xie, Liandi& Wang, Yao& Wu, Shuang& Liu, FengZhi& Zhang, Shuangshuang…[et al.]. Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157497