Determination of Ten Corticosteroids in Illegal Cosmetic Products by a Simple, Rapid, and High-Performance LC-MSMS Method
Joint Authors
Ferrantelli, Vincenzo
Cammilleri, Gaetano
Macaluso, Andrea
Giaccone, Vita
Polizzotto, Giuseppe
Source
International Journal of Analytical Chemistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of our present work was the development of a rapid high-performance liquid chromatography method with electrospray ionization and tandem mass spectrometry detection (LC-ESI-MS/MS) for the determination of several corticosteroids in cosmetic products.
Corticosteroids are suspected to be illegally added in cosmetic preparations in order to enhance the curative effect against some skin diseases.
Sample preparation step consists in a single extraction with acetonitrile followed by centrifugation and filtration.
The compounds were separated by reversed-phase chromatography with water and acetonitrile (both with 0.1% formic acid) gradient elution and detected by ESI-MS positive and negative ionization mode.
The method was validated at the validation level of 0.1 mg kg−1.
Linearity was studied in the 5–250 μg L−1 range and linear coefficients (r2) were all over 0.99.
The accuracy and precision of the method were satisfactory.
The LOD ranged from 0.085 to 0.109 mg kg−1 and the LOQ from 0.102 to 0.121 mg kg−1.
Mean recoveries for all the analytes were within the range 91.9–99.2%.
The developed method is sensitive and useful for detection, quantification, and confirmation of these corticosteroids in cosmetic preparations and can be applied in the analysis of the suspected samples under investigation.
American Psychological Association (APA)
Giaccone, Vita& Polizzotto, Giuseppe& Macaluso, Andrea& Cammilleri, Gaetano& Ferrantelli, Vincenzo. 2017. Determination of Ten Corticosteroids in Illegal Cosmetic Products by a Simple, Rapid, and High-Performance LC-MSMS Method. International Journal of Analytical Chemistry،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1157527
Modern Language Association (MLA)
Giaccone, Vita…[et al.]. Determination of Ten Corticosteroids in Illegal Cosmetic Products by a Simple, Rapid, and High-Performance LC-MSMS Method. International Journal of Analytical Chemistry No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1157527
American Medical Association (AMA)
Giaccone, Vita& Polizzotto, Giuseppe& Macaluso, Andrea& Cammilleri, Gaetano& Ferrantelli, Vincenzo. Determination of Ten Corticosteroids in Illegal Cosmetic Products by a Simple, Rapid, and High-Performance LC-MSMS Method. International Journal of Analytical Chemistry. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1157527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157527