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Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method
Joint Authors
Wagiealla Shantier, Shaza
Ahmed Gadkariem, Elrasheed
Awadalla Mohamed, Magdi
Akode, Ruaa Mohamed
Source
International Journal of Analytical Chemistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This work presents UV first derivative spectrophotometry as a precise, accurate, and feasible method for simultaneous determination of diminazene diaceturate and phenazone in bulk and dosage forms.
The absorbance values of diminazene diaceturate and phenazone aqueous mixture were obtained at 398 nm and 273 nm, respectively.
The developed method was proved to be linear over the concentration ranges (2–10) μg/mL and (2.496–12.48) μg/mL for diminazene diaceturate and phenazone, respectively, with good correlation coefficients (not less than 0.997).
The detection and quantitation limits were found to be (LOD = 0.63 and 0.48 μg/mL; LOQ = 1.92 and 1.47 μg/mL, resp.).
The developed method was employed for stability studies of both drugs under different stress conditions.
Diminazene diaceturate was prone to degrade at acidic pH via first-order kinetics.
The degradation process was found to be temperature dependent with an activation energy of 7.48 kcal/mole.
Photo-stability was also investigated for this drug.
American Psychological Association (APA)
Akode, Ruaa Mohamed& Wagiealla Shantier, Shaza& Ahmed Gadkariem, Elrasheed& Awadalla Mohamed, Magdi. 2017. Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method. International Journal of Analytical Chemistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1157536
Modern Language Association (MLA)
Akode, Ruaa Mohamed…[et al.]. Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method. International Journal of Analytical Chemistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1157536
American Medical Association (AMA)
Akode, Ruaa Mohamed& Wagiealla Shantier, Shaza& Ahmed Gadkariem, Elrasheed& Awadalla Mohamed, Magdi. Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method. International Journal of Analytical Chemistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1157536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157536