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Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke
Joint Authors
Wang, Meng
Ding, Yuchuan
Lee, Hangil
Elkin, Kenneth
Bardhi, Redina
Guan, Longfei
Chandra, Ankush
Geng, Xiaokun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy, a physiologic mechanism that promotes energy recycling and orderly degradation through self-regulated disassembly of cellular components, helps maintain homeostasis.
A series of evidences suggest that autophagy is activated as a response to ischemia and has been well-characterized as a therapeutic target.
However, the role of autophagy after ischemia remains controversial.
Activated-autophagy can remove necrotic substances against ischemic injury to promote cell survival.
On the contrary, activation of autophagy may further aggravate ischemic injury, causing cell death.
Therefore, the present review will examine the current understanding of the precise mechanism and role of autophagy in ischemia and recent neuroprotective therapies on autophagy, drug therapies, and nondrug therapies, including electroacupuncture (EA).
American Psychological Association (APA)
Wang, Meng& Lee, Hangil& Elkin, Kenneth& Bardhi, Redina& Guan, Longfei& Chandra, Ankush…[et al.]. 2020. Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157540
Modern Language Association (MLA)
Wang, Meng…[et al.]. Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157540
American Medical Association (AMA)
Wang, Meng& Lee, Hangil& Elkin, Kenneth& Bardhi, Redina& Guan, Longfei& Chandra, Ankush…[et al.]. Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157540