Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial
Joint Authors
Du, Yiqi
Wang, Lina
Yue, Xiaoqiang
Qi, Xiuzhong
Yang, Fangyong
Chen, Yan
Wang, Meitang
Huang, Haitao
Zhu, Dezeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The red peony root derived from Paeonia lactiflora has been applied to treat human inflammatory diseases.
To investigate its therapeutic potential in treating moderately severe acute pancreatitis (MSAP), which has been rarely studied, this study was designed as a double-blinded, placebo-controlled, randomized clinical trial.
A total of 60 MSAP patients were enrolled and randomly divided into an experimental (n = 30) group and a control group (n = 30), who received a coloclyster of 15 g of red peony root or placebo granules dissolved in 150 mL of water, respectively.
The patients’ demographic and clinical characteristics were recorded.
The results showed that the experimental group had a shorter remission time of fever (p<0.05) and abdominal pain (p<0.01) and faster resumption of self-defecation (p<0.01) than did the control group.
In addition, the coloclyster of red peony root decreased the modified Balthazar CT score as well as the serum interleukin-6 and tumor necrosis factor-alpha levels to a greater extent than did the placebo coloclyster (p<0.05).
The remission times for the normalization of white blood cells and percentage of neutrophils and lymphocytes in the experimental group were also significantly shorter than those in the control group (p<0.05).
In conclusion, a coloclyster of red peony root could help alleviate the clinical symptoms and shorten the course of MSAP by possibly attenuating systematic inflammation.
This trial is registered with 14004664.
American Psychological Association (APA)
Yang, Fangyong& Qi, Xiuzhong& Du, Yiqi& Chen, Yan& Wang, Meitang& Huang, Haitao…[et al.]. 2020. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157583
Modern Language Association (MLA)
Yang, Fangyong…[et al.]. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157583
American Medical Association (AMA)
Yang, Fangyong& Qi, Xiuzhong& Du, Yiqi& Chen, Yan& Wang, Meitang& Huang, Haitao…[et al.]. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157583