Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes
Joint Authors
Benbacer, Laila
Ullah, Riaz
Bourhia, Mohammed
Bari, Ahmed
Bousta, Dalila
Moussa, Samir Iben
Amrati, Fatima ez-zahra
Slighoua, Meryem
Amaghnouje, Amal
Di Cristo, Francesca
Calarco, Anna
El Mzibri, Mohamed
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Caralluma europaea (C.
europaea) is a medicinal plant used in Moroccan popular medicine.
Objective of the Study.
The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C.
europaea.
Materials and Methods.
The chemical composition was analyzed using HPLC.
The antioxidant power was determined using both DPPH and FRAP assays.
The antiproliferative activity was effectuated against cancerous cells using WST-1.
Results.
The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin.
The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively.
The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively.
The obtained IC50 values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively.
Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62 μg/ml).
The flavonoids decreased the cell viability with IC50 values of 43.62 ± 0.06 μg/ml, whereas the hydroethanolic extract and mucilages were ineffective.
Saponins were also effective against MCF-7 cells with IC50 values of 4.195 ± 0.025 μg/ml.
Conclusion.
The present results suggest that C.
europaea may have considerable potential for the development of effective natural anticancer agents.
American Psychological Association (APA)
Amrati, Fatima ez-zahra& Bourhia, Mohammed& Slighoua, Meryem& Moussa, Samir Iben& Bari, Ahmed& Ullah, Riaz…[et al.]. 2020. Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157587
Modern Language Association (MLA)
Amrati, Fatima ez-zahra…[et al.]. Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157587
American Medical Association (AMA)
Amrati, Fatima ez-zahra& Bourhia, Mohammed& Slighoua, Meryem& Moussa, Samir Iben& Bari, Ahmed& Ullah, Riaz…[et al.]. Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157587