Investigation of the Potential Mechanism Governing the Effect of the Shen Zhu San on COVID-19 by Network Pharmacology
Joint Authors
Wang, Yuxuan
Ru, Yuhua
Zhuo, Guowei
Sheng, Maozheng
Wang, Shuangqiu
Ma, Jiarui
Zhou, Chongyi
Sun, Xiaohe
Zeng, Yanqi
Zhang, Ya
Li, Hui
Lu, Zhigang
Wu, Depei
Wu, Minghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-09
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Background.
Since December 2019, coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 infection has emerged in Wuhan and rapidly spread throughout China and even to other countries.
Combined therapy with modern medicine and traditional Chinese medicine has been proposed, in which Shen Zhu San (SZS) was regarded as one of the basic prescriptions.
Methods.
Network pharmacological approaches along with candidate compound screening, target prediction, target tissue location, protein-protein interaction network, gene ontology (GO), KEGG enrichment analyses, and gene microarray analyses were applied.
Results.
A total of 627 targets of the 116 active ingredients of SZS were identified.
Targets in immune cells and tissues were much more abundant than those in other tissues.
A total of 597 targets were enriched in the GO biological cellular process, while 153 signaling pathways were enriched according to the KEGG analysis.
A total of 450 SARS-related targets were integrated and intersected with the targets of SZS to identify 40 common targets that were significantly enriched in five immune function aspects of the immune system process during GO analysis.
Several inflammation-related pathways were found to be significantly enriched throughout the study.
Conclusions.
The therapeutic mechanisms of the effects of SZS on COVID-19 potentially involve four effects: suppressing cytokine storms, protecting the pulmonary alveolar-capillary barrier, regulating the immune response, and mediating cell death and survival.
American Psychological Association (APA)
Wang, Yuxuan& Ru, Yuhua& Zhuo, Guowei& Sheng, Maozheng& Wang, Shuangqiu& Ma, Jiarui…[et al.]. 2020. Investigation of the Potential Mechanism Governing the Effect of the Shen Zhu San on COVID-19 by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1157630
Modern Language Association (MLA)
Wang, Yuxuan…[et al.]. Investigation of the Potential Mechanism Governing the Effect of the Shen Zhu San on COVID-19 by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1157630
American Medical Association (AMA)
Wang, Yuxuan& Ru, Yuhua& Zhuo, Guowei& Sheng, Maozheng& Wang, Shuangqiu& Ma, Jiarui…[et al.]. Investigation of the Potential Mechanism Governing the Effect of the Shen Zhu San on COVID-19 by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1157630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157630